https://journal.unhas.ac.id/index.php/ica/issue/feed Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) 2020-08-24T22:36:53+00:00 Indonesia Chimica Acta Journal (ICAJ) ica@unhas.ac.id Open Journal Systems <p align="justify">Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of chemistry. The result of research and development in the fields of chemistry in both experimental and theory/ computation, chemical-based technological innovations, and chemical applications in industrial fields. The journal publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry. Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is a journal published by Department of Chemistry Faculty of Mathematics and Natural Sciences, Hasanuddin University, where it was published twice in a year in June and December.</p><p align="justify">The Journal has been accredited by Akreditasi Jurnal Nasional (ARJUNA) officially Managed by Ministry of Research, Technology, and Higher Education, Republic Indonesia with Third Grade (SINTA 3) since year 2019 to 2023 according to the decree <a title="SK" href="http://arjuna.ristekdikti.go.id/files/berita/Pemberitahuan_Hasil_Akreditasi_Jurnal_Ilmiah_Periode_V_Tahun_2019.pdf" target="_blank">Number 28/E/KPT/2019</a>.</p><p><strong>p-ISSN: <strong><a title="ISSN Print" href="http://issn.pdii.lipi.go.id/issn.cgi?daftar&amp;1230708657&amp;1&amp;&amp;" target="_blank">2085-014X</a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </strong></strong><strong>e-ISSN: <a title="ISSN Online" href="http://issn.pdii.lipi.go.id/issn.cgi?daftar&amp;1544263050&amp;1&amp;&amp;" target="_blank"><strong>2655-6049</strong></a></strong></p> https://journal.unhas.ac.id/index.php/ica/article/view/11138 REVIEW: PHYTOCHEMICAL SCREENING, SECONDARY METABOLITES AND BIOLOGICAL ACTIVITIES OF SOUTHEAST SULAWESI PLANTS 2020-08-24T22:36:53+00:00 Megawati Megawati megawatichem@gmail.com Southeast Sulawesi is one of the provinces in Indonesia which has a variety of medicinal plants that have been used by its people in treating diseases. The results of research on phytochemical screening and isolation of secondary metabolites from local researchers indicated that the plants from Southeast Sulawesi have the potential to be studied further. Plants from Southeast Sulawesi show pharmacological potential activities that can be developed for the purpose of treating diseases caused by bacteria, fungi, cancer, and as an antioxidants. There are Southeast Sulawesi endemic plants from the <em>Etlingera </em>genus that are interesting to explore (phytochemical screening, isolation of pure compounds and pharmacological studies) considering that of the 14 species of Etlingera plants scattered in Southeast Sulawesi, 2 (two) of which have recently been reported, namely <em>E. elatior</em> and <em>E. calophrys</em> Copyright (c) Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) https://journal.unhas.ac.id/index.php/ica/article/view/10962 A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells 2020-08-04T13:24:43+00:00 Firdaus Firdaus firdaus@unhas.ac.id Nunuk Hariani Soekamto noek_1512@yahoo.com Syadza Firdausiah syadzafirdausiah@unhas.ac.id Musrifah Tahar musrifah_tahar@yahoo.co.id Some<strong> </strong>esters and amide derivatives of <em>p</em>-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely <em>N</em>-(piperidinyl)caffeamide (<strong>M5</strong>) and its anticancer activity assay, has been conducted. The compound <strong>M5</strong> was synthesized using <em>p</em>-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound <strong>M5</strong> was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC<sub>50</sub> value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized. Copyright (c) Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) https://journal.unhas.ac.id/index.php/ica/article/view/10820 Caffeic Acid Derivatives Potential for Anticancer Drugs: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells 2020-08-03T15:37:33+00:00 Firdaus Firdaus firdaus@unhas.ac.id Nunuk Hariani Soekamto noek_1512@yahoo.com Syadza Firdausiah syadzafirdausiah@unhas.ac.id Musrifah Tahar musrifah_tahar@yahoo.co.id Some<strong> </strong>esters and amide derivatives of <em>p</em>-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely <em>N</em>-(piperidinyl)caffeamide (<strong>M5</strong>) and its anticancer activity assay, has been conducted. The compound <strong>M5</strong> was synthesized using <em>p</em>-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound <strong>M5</strong> was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC<sub>50</sub> value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized. Copyright (c) Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) https://journal.unhas.ac.id/index.php/ica/article/view/10771 Antibacterial activity test of elephant ginger (Zingiber officinale Rosc.) Endophytic fungi variation of elephants against bacteria that cause skin infections 2020-07-23T04:11:26+00:00 seniwati seniwati seniwatid@gmail.com Laras Aprilia laras_aprilia@gmail.com Rusli Rusli rusli@umi.ac.id Tadjuddin Naid tadju1946@gmail.com <em>Elephant ginger rhizome has the potential as an antibacterial, therefore the research was conducted to test the antibacterial activity of elephant ginger endophytic fungi against bacteria that cause skin infections, determine test bacteria that can be inhibited by elephant ginger endophytic fungi and bioautogram profile for its antibacterial activity. Isolation of endophytic ginger elephant fungi using the direct planting method. Screening of endophytic fungi isolates was placed on the surface of NA medium containing test bacteria Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acne. The screening results obtained were 2 isolates namely isolates which had the highest activity namely IFDRJG03 and IFDRJG04. For IFDRJG03 isolates can inhibit the antibacterial activity of Staphylococcus aureus 25.26 mm, Staphylococcus epidermidis 26.89 mm and Propionibacterium acne 27.12 mm, IFDRJG04 isolates can inhibit the antibacterial activity of Staphylococcus aureus 15.87 mm, Staphylococcus epidisidis 18 and 96 mm. 27.43 mm. Then the TLC-Bioautography test was carried out, the results of IFDRJG03 isolates were obtained using chloroform eluents: methanol (1: 1) had antibacterial activity against Staphylococcus aureus with Rf1 = 0.9 and Rf2 = 0.5, Staphylococcus epidermidis with Rf1 value = 0.8 and Rf2 = 0.5 and Propionibacterium acne with Rf1 value = 0.9 and Rf2 = 0.5 and isolation of IFDRJG04 isolates with ethyl acetate eluent: ethanol: water (8: 2: 1) has antibacterial activity against Staphylococcus aureus Rf1 values = 0.9 Rf2 = 0.7 Rf3 = 0.6, Staphylococcus epidermidis with Rf1 value = 0.7 Rf2 = 0.6, Rf3 = 0.5 and Propionibacterium acne with Rf1 value = 0.9 and Rf2 = 0.7.</em><p class="04-abstract"><em>lephant ginger rhizome has the potential as an antibacterial, therefore the research was conducted to test the antibacterial activity of elephant ginger endophytic fungi against bacteria that cause skin infections, determine test bacteria that can be inhibited by elephant ginger endophytic fungi and bioautogram profile for its antibacterial activity. Isolation of endophytic ginger elephant fungi using the direct planting method. Screening of endophytic fungi isolates was placed on the surface of NA medium containing test bacteria Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acne. The screening results obtained were 2 isolates namely isolates which had the highest activity namely IFDRJG03 and IFDRJG04. For IFDRJG03 isolates can inhibit the antibacterial activity of Staphylococcus aureus 25.26 mm, Staphylococcus epidermidis 26.89 mm and Propionibacterium acne 27.12 mm, IFDRJG04 isolates can inhibit the antibacterial activity of Staphylococcus aureus 15.87 mm, Staphylococcus epidisidis 18 and 96 mm. 27.43 mm. Then the TLC-Bioautography test was carried out, the results of IFDRJG03 isolates were obtained using chloroform eluents: methanol (1: 1) had antibacterial activity against Staphylococcus aureus with Rf1 = 0.9 and Rf2 = 0.5, Staphylococcus epidermidis with Rf1 value = 0.8 and Rf2 = 0.5 and Propionibacterium acne with Rf1 value = 0.9 and Rf2 = 0.5 and isolation of IFDRJG04 isolates with ethyl acetate eluent: ethanol: water (8: 2: 1) has antibacterial activity against Staphylococcus aureus Rf1 values = 0.9 Rf2 = 0.7 Rf3 = 0.6, Staphylococcus epidermidis with Rf1 value = 0.7 Rf2 = 0.6, Rf3 = 0.5 and Propionibacterium acne with Rf1 value = 0.9 and Rf2 = 0.7.<strong> </strong></em></p> Copyright (c) Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) https://journal.unhas.ac.id/index.php/ica/article/view/10747 Seasonal variations of major anions in water at Baro haor area of kishoreganj, bangladesh and revealing the suitability of water for aquatic resource management 2020-07-20T08:29:39+00:00 Shamim Al Mamun shamim084du@yahoo.com <p>Haors are areas with sweet water that inhabits a large variety of fishes and other aquatic animals. The quality of water in haors affects the lives in haors and the deterioration of the quality of water due to different anthropogenic reasons may affect the total ecosystem of haors. The study was conducted to investigate the physicochemical parameters and major anions of water of Baro haor area in Kishoreganj during the period from September 2016 to August 2017. The water samples were collected monthly during the pre-monsoon (Feb. to May), monsoon (Jun. to Sep.) and post-monsoon (Oct. to Jan.) seasons from five sampling stations as: (i) Bayershuil beel (St-1), (ii) Tegulia beel (St-2), (iii) Singpur beel (St-3), (iv) Neora beel (St-4) and (v) Bara beel (St-5). The physicochemical water quality was analyzed in the laboratory of the Department of Environmental Science and Resource Management (ESRM), Mawlana Bhashani Science and Technology University (MBSTU), whereas, anions were analyzed in Bangladesh Institute of Nuclear Agriculture (BINA), Mymensingh. Results of the study showed that the mean temperature, electrical conductivity (EC), total dissolved solid (TDS), dissolved oxygen (DO), biochemical oxygen demand (BOD), pH, alkalinity and hardness were found 28.03°C, 696.70 µS/cm, 484.35 mg/L, 6.62 mg/L, 2.36 mg/L, 7.40, 291.35 mg/L and 106.85 mg/L, respectively which revealed that the water was suitable for aquatic environment as well as fish production. Mean concentration of fluoride (F<sup>-</sup>), chloride (Cl<sup>-</sup>), bromide (Br<sup>-</sup>), nitrite (NO<sub>2</sub><sup>-</sup>), nitrate (NO<sub>3</sub><sup>-</sup>) and sulfate (SO<sub>4</sub><sup>2-</sup>) were 0.35, 121.35, 0.15, 5.63, 28.41 and 66.29 mg/L, respectively. The water quality was found suitable for aquatic environment and for fish production but the haor area is highly subjected to anthropogenic disturbances. To conserve the aquatic environment of the Baro haor regular monitoring and management should be taken to maintain the water quality.</p> Copyright (c) Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta)