Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta)

PROFILING OF MODIFIED CHITOSAN-BASED COMPOSITES AS TETRACYCLINE HYDROCHLORIDE DRUG RELEASE SYSTEMS

Nurul Anjartikasari

Controlled drug release systems (DDS) are a crucial technology in the medical field, and they continue to be developed today. Chitosan is useful in manufacturing-controlled drug release systems due to its non-toxic, biodegradable, and biocompatible properties. However, it has some limitations when it comes to its physical and mechanical properties. Combining chitosan with other materials, such as bacterial cellulose (BC), graphite (Gr), ZnO, and TiO₂, can improve its mechanical properties and antibacterial activity. This study aims to synthesize Chi/BC/Gr/ TiO₂ and Chi/BC/Gr/ZnO composites as drug release systems. When tested with TCH, an antibiotic model, the drug release kinetics of the composite followed the Hixson-Crowell and Korsmeyer Peppas kinetics models. Additional tests for physical and mechanical properties, as well as antibacterial activity, have also been conducted.

Synthesis of Gold (Au) Nanoparticles by using Bioreductor of Cocoa (Theobroma cacao L.) Rind Extract and It's Antibacterial Activity Test

Fabriani Sabir

Research on the Synthesis of Gold (Au) Nanoparticles by using Bioreductor

of Cocoa (Theobroma cacao L.) Rind Extract and Its Antibacterial Activity Test has been

done. This Green Synthesis method uses methanol as a solvent to extract organic

compounds in the cocoa rind that function as bioreductants. The results of the synthesis

were continued by testing its activity as an antibacterial. The form of gold nanoparticles

can be confirmed after 30 minutes of stirring. The characterization of gold nanoparticles

was carried out using a UV-Vis spectrophotometer, Fourier Transform Infrared (FTIR),

X-Ray Diffraction (XRD), and Scanning Electron Microscopy-Energy Dispersive X-Ray

(SEM-EDX). Based on the analysis of UV-Vis spectrophotometer, the maximum

wavelength was at 553 nm with an absorbance value of 0.164. The FTIR results indicate

the presence of a hydroxyl group that acts as a metal ion reducing agent so that it is not

charged, while the results of the XRD analysis confirm that the gold nanoparticle crystals

are Face Centered Cubic (FCC) and based on the Scherrer approach the particle size

distribution has an average diameter of 6.303 nm. The SEM-EDX results showed that

the gold nanoparticles had a spherical shape and were located in the M electron shell.

The gold nanoparticles had an inhibitory zone of 8.9 mm in Pseudomonas aeruginosa

and 7.6 mm in Bacillus subtilis bacteria.

Membranes with Chitosan-Chitosan/Phthalate Matrix and Montmorillonite-Carbon Nanotubes Filler for DMFC Applications

Loth Botahala

Composite membranes consist of matrix and filler. The matrices used are chitosan (K) and chitosan-phthalate (KF). Meanwhile, the filler used is montmorillonite coated with carbon nanotubes (MMT-CNT). The membrane was made using the phase inversion method and solvent evaporation. The physical characterization carried out was FTIR, XRD, and SEM. Meanwhile, for characterization of membrane performance, namely swelling, methanol uptake, ion exchange capacity, methanol permeability, proton conductivity, and TGA. The results of this characterization showed that the optimum membrane was found at K 1.96 - KF 0.09/ MMT-CNT. In this membrane, methanol permeability was found to be 2.64x10^-6 cm²/s, proton conductivity was 3.352x10^-6 S/cm, selectivity was 1.2714 Ss/cm³, and membrane stability was at a temperature of 290℃. so the optimum composition is K 1.96 grams, KF 0.09 grams, and MMT-CNT 0.129 grams.

ANTIDIABETIC ANALYSIS FROM METHANOL EXTRACT OF Merremia Vitofilia LEAF USING IN-VITRO AND IN-SILICO METODS

Sukarti Sukarti

One of the plants that is highly trusted as a wound medicine for diabetes (ulcer) sufferers by the people of Luwu Raya, South Sulawesi is the leaves of Akar Bulu (Merremia vitofilia). So far, The antibidiabetic activiity of this plant is known. Therefore, the aim of this study was to determine the antideabetic activity of Extract Merremia vitofilia leaf using in-vitro and silico test. This research went trough the stages of sample preparation, extraction, GC MS test, in vitro antidiabetic activity test and in silico test of the methanol extract of M. Vitofilia leaves. The results of research carried out in vitro showed the M. Vitofilia leaf extract had and IC₅₀ value 0f 207.9605 for α-glucosidase enzyme activity. Results of the in silico antidiabetic metods through molecular docking analysis, it is known that of the 2-[3-cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]-N-(3,4-dichlorophenyl)acetamide Compound (A3) and 3-benzoyloxy-5-methylphenyl) benzoate Compound (A4) have the potential to be antidiabetic, because they have bond energies below -5 Kcal/mol, namely -7.95 and -7.99 Kcal/mol.

Theoretical Study of Metal Ion Impact on Geometry and Bond Vibrational Properties of Salophen Compound

Tety Wahyuningsih Manurung

Coordination compounds are a class of compounds consisting of a central metal ion surrounded by ligands. These compounds exhibit a wide array of applications, ranging from catalysis and sensors to pharmaceuticals. Theoretical modeling research has emerged as a rapidly developing field, employing computational chemistry techniques to predict the properties of coordination compounds, including their structure, energy, and spectroscopic features.Salophen, an organic compound, possesses the ability to form coordination compounds with various metal ions. Its four lone pair electron donor atoms serve as binding sites for metal ions, establishing coordination bonds.The PM6 semiempirical method was employed to model the geometry, electronic, and vibrational properties of salophen ligand and its complexes with Zn, Cd, and Hg metal ions