Development Michrosphere Bioadhesive Delivery System From Secondary Metabolit Actynomycetes M10a Rhizosphere Mangrove As Supportive Therapy of Colon Cancer Patients
Abstract
Colon cancer is a cancer that occurs in the large intestine when abnormal cells growin the colon or rectum layer. Inflammation Symptoms in the colon are usually characterized
by a polyp that has cancer risk. Approximately 96% of colon cancer cases are caused by
adenocarcinomas that develop from the glandular tissue. Utilization of secondary metabolites
from Actynomycetes Mangrove forests can be used as supportive therapy for colon cancer
patients that have already through apoptotic testing so it can directly treat the target of illness.
This study was prepared in the form of Michrosphere Bioadhesive using secondary
metabolite Actynomycetes M10a rhizosphere mangrove. The purpose of this study was to
obtain the development of Michosphere Bioadhesive preparations from secondary
metabolites Actynomycetes M10a rhizosphere mangrove as supportive therapy for colon
cancer patients. Method of the research is base on Laboratory experiment which started with
Purification of Actynomycetes isolate, Secondary Metabolite Fermentation, Michrosphere
Bioadhesive Formulation and evaluation of Michrosphere Bioadhesive preparation. The
concentration of secondary metabolite Actynomycetes M10a rhizosphere mangrove that been
used for each formula are 400 μl, 500 μl, and 600 μl, where the percentage of submerged in
F1, F2, and F3 are 93,94%, 96,96%, and 94, respectively, 12%. Particular Particle Size
Distribution is F1 (3.1μm), F2 (4.4 μm), F3 (3.9 μm). The rest angles obtained are F1
(0.002O), F2 (0.002O), F3 (0.0016O), respectively. Applied efficiency was obtained by F1
(214 nm), F2 (210 nm), F3 (211 nm). Dissolution results show the absorbance results at 266
nm wavelength. From the results obtained that meet the specifications seen in Formula 2.
Keywords: Colon Cancer, Actynomycetes M10a rhizosphere mangrove, Michosphere
Bioadhesive.
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