Histopathologic features of male domestic cat (Felis domestica) testes induced by bisphenol-A orally

Authors

Fachira Ulfa Makmur Study Program of Veterinary Medicine, Faculty of Medicine, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia
Fika Yuliza Purba Study Program of Veterinary Medicine, Faculty of Medicine, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia
Dwi Kesuma Sari Study Program of Veterinary Medicine, Faculty of Medicine, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, Indonesia http://orcid.org/0000-0002-5326-3336

Keywords:

histopathology, testes, cats, bisphenol-A (BPA), estrogenic effect

Abstract

Infertility in cat becomes a serious problem in pet community since many compounds of infertility-caused can be found widely in the environment. One of the compounds causing infertility in mammals is Bisphenol-A (BPA), which is known as an estrogenic compound. The purpose of this research is to observe the changes in testicular histology of male domestic cat (Felis domestica) induced by BPA orally. Sample used in this study were 24 male domestic cats divided into 4 groups, namely the group 1 as control, group 2, 3 and 4 were treated with BPA about 5, 10 and 100 mg/kg bodyweight, respectively for 5 days. The results showed that the estrogenic effect of BPA affects the reproductive system of the cat. The effects of BPA in cat included decrease in the amounts of spermatozoa, vacuolization of seminiferous tubules cells, degeneration of Leydig cells, degeneration of tubular epithelial cells, irregular forms of the germ, interstitial tissue hemorrhage, debris cell filled the lumen of seminiferous tubules. These results suggested that BPA can be harmful to the reproductive system of the cat

References

Anonim. 2003. Bisphenol A. http://www.bisphenol-a.org/about/index.html. Diakses [27 Agustus 2015].

Bacha Jr, William J. dan Bacha LM. 2000. Color Atlas Of Veterinary Histology, Second Edition. Lippincott Williams &Wilkins : United States Of America.

Bailey AB dan Hoekstra EJ. 2010. FAO/WHO Expert Meeting on Bisphenol A (BPA): Sourcesand Occurrence of Bisphenol A Relevant for Exposure of Consumers. http://www.who.int/foodsafety/chem/chemicals/2_source_and_occurrence.pdf.[08 maret 2014].

Balthazart J., Hendrick JC. 1978. Steroidal control of plasma luteinizing hormone, comb growth and sexual behavior in male chicks. J. Endocrinol. 77:149–150.

Berger, RG., Shaw, J., de Catanzaro, D. 2008. Impact of acute bisphenol-A exposure upon intrauterine implantation of fertilized ova and urinary levels of proges- terone and 17 beta-estradiol. Reprod. Toxicol. 26: 94-99.

Chaboud, I., Fialkowski, O., Talsness, CE. 2001. The effects of low and high dose in utero exposure to bisphenol A on the reproductive system of male rat offspring. Reprod. Toxicol. 15: 589

Creasy, DM. 2001. Pathogenesis of male reproductive toxicity. Toxicol. Pathol. 29: 64–76.

Creasy, DM. 2012. Proliferative and Nonproliferative Lesions of the Rat and Mouse Male Reproductive System. Toxicol. Pathol. 40: 40S-121S.

Dodds, EC., Lawson, W. 1936. Synthetic estrogenic agents without the phenanthrene nucleus. Nature, 137: 996.

Ema, M., Fujii, S., Furukawa, M., Kiguchi, M., Ikka, T., and Harazono, A. 2001. Reprod. Toxicol. 15: 505-523.

Ezer, N., and Robaire, B. 2002. Androgenic regulation of the structure and functions of the epididymis. In The Epididymis: From Molecules to Clini- cal (B. Robaire and B. T. Hinton, eds.). Kluwer Academic/ Plenum publishers, New York, NY. pp. 297–316.

Furuya, M., Adachi, K., Kuwahara, S., Ogawa, K., Tsukamoto, Y. 2006. Inhibition of male chick phenotypes and spermatogenesis by Bisphenol-A. Life Sciences, 78 (15): 1767-1776. DOI: 10.1016/j.lfs.2005.08.016

Furuya, M., Sasaki, F., Hassanin, AMA., Kuwahara, S., and Tsukamoto, Y. 2002. Effects of bisphenol-A on the growth of comb and testes of male chicken. Canadian J. Veterinary Research. 67: 68-71.

Grün, F., Blumberg, B., 2009. Endocrine disrupters as obesogens. Mol. Cell. Endo- crinol. 304: 19-29.

Gurmeet, KSS., Rosnah, I., Normadiah, MK., Das, S. and Mustafa, AM. 2014. Detrimental effects of bisphenol A on development and functions of the male reproductive system in experimental rats. EXCLI Journal. University of Malaya. Malaysia. Kuala lumpur.

Guyton AC., Hall JE. 2005. Buku Ajar Fisiologi Kedokteran. Ed ke-11. Philadelphia: W.B Saunders Company. Terjemahan: dari Textbook of Medical Physiology. p: 1265-1277

Guyton AC, Hall JE. Textbook of medical physiology. 11th ed. Pennsylvania: Elsevier Inc; 2006. p. 1011-22.

Harneit, S., Paust, H. J., Mukhopadhyay, AK., and Ergun, S. (1997). Localization of endothelin 1 and endothelin receptors A and B in human epididymis. Mol. Hum. Reprod. 3: 579–84.

Hess, RA. 2002. The efferent ductules: Structure and function. Kluwer Academic/Plenum Publishers, New York, NY. pp. 49–80.

Howdeshell, KL., Hotchkiss, AK., Thayer, KA., Vandenbergh, JG., vom Saal, FS. 1999. Exposure to bisphenol A advances puberty. Nature. 410: 763-764.

Hunt, PA., Susiarjo, M., Rubio, C., Hassold, T. 2009. The Bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction. Biol. Reprod. 81: 807-813.

Jana, K., and Samanta, PK. 2006. Evaluation of single intratesticular injection of calcium chloride for nonsurgical sterilization in adult albino rats. Contraception 73, 289–300.

Kerr, JB., Savage, GN., Millar, M., and Sharpe, RM. 1993. Response of the seminiferous epithelium of the rat testis to withdrawal of androgen: Evidence for direct effect upon intercellular spaces associated with Sertoli cell junctional complexes. Cell. Tissue. Res. 274: 153–61.

Lusda MIK. 2013. Kajian Paparan Bisphenol-A dari Botol Susu Polikarbonat dalam ASI dan Air pada Bayi. Skripsi. Fakultas Teknologi Pertanian Institut Pertanian Bogor.

Maruyama, S. Fujimoto, S., Yin, H., Ito, A. 1999. Growth stimulation of a rat pituitary cell line MtT/E-2 by environmental estrogens in vitro and in vivo. Endocrinol. J., 46: 513-520.

Radovsky, A., Mitsumori, K., and Chapin, RE. 1999. Male reproductive tract in pathology of the mouse, reference and atlas. Cache River Press, Vienna. pp. 381–407.

Tyl, RW., Myers, CB., Marr, MC., Thomas, BF., Keimowitz, AR., Brine, DR., Veselica, MM., Fail, FA, Chang, TY., Seely, JC., Joiner, RL., Butala, JH., Dimond, SS., Cagen, SZ., Shiotsuka, RN., Stropp, GD., and Waechter, JM. 2002, "Three-generation reproductive toxicity study of dietary Bisphenol A in CD Sprague-Dawley Rats," Toxicological Sciences. 68: 121-146.

Yan, W., Samson, M., Jegou, B., and Toppari, J. 2000. Bcl-w forms complexes with Bax and Bak, and elevated ratios of Bax/Bcl-w and Bak/Bcl-w correspond to spermatogonial and spermatocyte apoptosis in the testis. Mol. Endocrinol. 14: 682–699.

Ulrich, B., Jochen, S., Günther, H., Helmut, S., Jürgen, B., Huber, C., and Roth W. 1988. Pharmacokinetics of Meloxicam in animals and the relevance to humans. Parmacol. 26 (3), 576-584.

Authors

Keywords:

Abstract

References

Downloads

Published

Issue

Section