Potentialy Of Flavonoid Miana (Coleus Atropurpereus) Leaves Estract As Anti Mycobacterium Tuberculosis H37rv Strain And Mdr With Microscopy Observation Drug Susceptibility (Mods)

Abstract

There is high resistance cases for Isoniazid and Rifampin and more famous with
Multi-drug resistant tuberculosis (MDR-TB). From data in Makassar, South sulawesi
showed 19,2 MDR-TB cases from new TB patient, and more 13,5% resistance cases for
firstline-TB drugs (STR, INH, RIF,and ETH), and >2 resistance for secondline-TB
drugs (OFL,KAN,AMK). Treatment for tuberculosis mostlly not effective because Multidrug
resistant

tuberculosis (MDR-TB) cases is very high.WHO recomended traditional
medicine for improvement of healthy in coummunity, preventive and pharmaceutical
preparation for all diseases. Research in 2013 showed 85,71% that Torajas TB patient
in South Sulawesi used traditional medicine such as Miana (Coleus atropurpereus)
leaves estract as complement for TB drugs. Our study showed flavonoid component from
qualitative method used sianida (HCl-Mg) from ethanol 96% Miana (Coleus
atropurpereus) leaves estract .Qualitative method using Spektrofotometer UV-V showed
the total of flavonoid component from ethanol 96% miana (Coleus atropurpereus) leaves
estract is 8,59 mgRE/gram ekstract.. The result showed were at concentrations (10%,
20% ,40 % , 60 % ,80 % and 100%) ethanol 96% miana (Coleus atropurpereus) leaves
estract were effecttively inhibit Mycobacterium tuberculosis H37RV strain. Were at
concentration (10%, 20% ,40 % dan 60 %) ethanol 96% miana (Coleus atropurpereus)
leaves estract were not effecttively inhibit MDR-TB but effecttively were at
concentration (80 % and 100%).