Effect of Probiotics as Therapeutical and Preventive Modality for Atopic Dermatitis; Lessons from Clinical Trials
Abstract
Introduction: Atopic dermatitis is a chronic relapsing inflammatory skin disease that can significantly impact patients' quality of life. Current therapy for atopic dermatitis is corticosteroids, calcineurin inhibitors, and immunosuppressants, but the recurrence of this disease is still reported, and their long-term use is vicious due to their immunosuppressive side effects; the need to discover a new modality that can be used as a therapeutical and preventive modality for atopic dermatitis. Probiotics have been well known for decades due to their various biological activities, including anti-inflammatory and immune-regulatory activity, that have many potential benefits for some skin diseases, including atopic dermatitis. Method: The method consisted of analyzing and evaluating relevant journal literature published within the past ten years. Result: Several clinical trials have proven the effectiveness of various species of Lactobacilli in improving clinical outcomes for children with atopic dermatitis. Clinical improvement of atopic dermatitis in children can be achieved not only through the administration of a single probiotic but also by combining different probiotic species. Conclusions: Based on those studies, probiotics are the potential therapeutical and preventive modality for atopic dermatitis and its primary possible mechanism.
References
1. Katayama I, Aihara M, Ohya Y, Saeki H, Shimojo N, Shoji S, et al. Japanese guidelines for atopic dermatitis 2017. Allergol Int [Internet]. 2017;66(2):230–47. Available from: http://dx.doi.org/10.1016/j.alit.2016.12.003
2. Waldman AR, Ahluwalia J, Udkoff J, Borok JF, Eichenfield LF. Atopic dermatitis. Pediatr Rev. 2018;39(4):180–93.
3. Avena-Woods C. Overview of atopic dermatitis. Am J Manag Care. 2017;23(8):S115–23.
4. Keles FF, Pandaleke HEJ, Mawu FO. Profil dermatitis atopik pada anak di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2013 – Desember 2015. e-CliniC. 2016;4(2).
5. Sidbury R, Kodama S. Atopic dermatitis guidelines: Diagnosis, systemic therapy, and adjunctive care. Clin Dermatol [Internet]. 2018;36(5):648–52. Available from: https://doi.org/10.1016/j.clindermatol.2018.05.008
6. Page SS, Weston S, Loh R. Atopic dermatitis in children. Aust Fam Physician. 2016;45(5):293–6.
7. Islam SU. Clinical Uses of Probiotics. Medicine (Baltimore). 2016;95(5):e2658.
8. Fang Z, Li L, Zhang H, Zhao J, Lu W, Chen W. Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review. Front Immunol. 2021;12(July):1–13.
9. Boothe WD, Tarbox JA, Tarbox MB. Atopic Dermatitis : Pathophysiology. :21–37.
10. Kim J, Kim BE, Leung DYM. Pathophysiology of atopic dermatitis: Clinical implications. Allergy Asthma Proc. 2019;40(2):84–92.
11. Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. Lancet [Internet]. 2020;396(10247):345–60. Available from: http://dx.doi.org/10.1016/S0140-6736(20)31286-1
12. Nakahara T, Kido-Nakahara M, Tsuji G, Furue M. Basics and recent advances in the pathophysiology of atopic dermatitis. J Dermatol. 2021;48(2):130–9.
13. Niccoli AA, Artesi AL, Candio F, Ceccarelli S, Cozzali R, Ferraro L, et al. Preliminary results on clinical effects of probiotic Lactobacillus salivarius LS01 in children affected by atopic dermatitis. J Clin Gastroenterol. 2014;48(February 2013):S34–6.
14. Han Y, Kim B, Ban J, Lee J, Kim BJ, Sun B, et al. SKIN AND EYE DISEASE A randomized trial of Lactobacillus plantarum CJLP133 for the treatment of atopic dermatitis. 2012;23:667–73.
15. Drago L, Toscano M, De Vecchi E, Piconi S, Iemoli E. Changing of fecal flora and clinical Effect of L. salivarius LS01 in adults with atopic dermatitis. J Clin Gastroenterol. 2012;46(SUPPL. 1):56–63.
16. Inoue Y, Kambara T, Murata N, Komori-Yamaguchi J, Matsukura S, Takahashi Y, et al. Effects of oral administration of lactobacillus acidophilus l-92 on the symptoms and serum cytokines of atopic dermatitis in japanese adults: A double-blind, randomized, clinical trial. Int Arch Allergy Immunol. 2014;165(4):247–54.
17. Matsumoto M, Ebata T, Hirooka J, Hosoya R, Inoue N, Itami S, et al. Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis. Ann Allergy, Asthma Immunol [Internet]. 2014; Available from: http://dx.doi.org/10.1016/j.anai.2014.05.002
18. Enrico Iemoli, Daria Trabattoni, Serena Parisotto, Linda Borgonovo, Marco Toscano, Giuliano Rizzardini, Mario Clerici, Elena Ricci, Alessandra Fusi, Elena De Vecchi, Stefania Piconi and LD. Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. J Clin Gastroenterol. 2012;46(1):33–40.
19. Fang Z, Lu W, Zhao J, Zhang H, Qian L, Wang Q, et al. Probiotics modulate the gut microbiota composition and immune responses in patients with atopic dermatitis: a pilot study. Eur J Nutr [Internet]. 2020;59(5):2119–30. Available from: https://doi.org/10.1007/s00394-019-02061-x
20. Drago L, De Vecchi E, Toscano M, Vassena C, Altomare G, Pigatto P. Treatment of atopic dermatitis eczema with a high concentration of Lactobacillus salivarius LS01 associated with an innovative gelling complex a pilot study on adults. J Clin Gastroenterol. 2014;48(December):S47–51.
21. Prakoeswa CRS, Herwanto N, Prameswari R, Astari L, Sawitri S, Hidayati AN, et al. Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis. Benef Microbes. 2017;8(5):833–40.
22. Wu YJ, Wu WF, Hung CW, Ku MS, Liao PF, Sun HL, et al. Evaluation of efficacy and safety of Lactobacillus rhamnosus in children aged 4–48 months with atopic dermatitis: An 8-week, double-blind, randomized, placebo-controlled study. J Microbiol Immunol Infect [Internet]. 2017;50(5):684–92. Available from: https://doi.org/10.1016/j.jmii.2015.10.003
23. Jeong K, Kim M, Jeon SA, Kim YH, Lee S. A randomized trial of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) for treating atopic dermatitis. Pediatr Allergy Immunol. 2020;31(7):783–92.
24. Yan DC, Hung CH, Sy LB, Lue KH, Shih IH, Yang CY, et al. A randomized, double-blind, placebo-controlled trial assessing the oral administration of a heat-treated lactobacillus paracasei supplement in infants with atopic dermatitis receiving topical corticosteroid therapy. Skin Pharmacol Physiol. 2019;32(4):201–11.
25. Ahn SH, Yoon W, Lee SY, Shin HS, Lim MY, Nam Y Do, et al. Effects of lactobacillus pentosus in children with allergen-sensitized atopic dermatitis. J Korean Med Sci. 2020;35(18):1–14.
26. Wang IJ, Wang JY. Children with atopic dermatitis show clinical improvement after Lactobacillus exposure. Clin Exp Allergy. 2015;45(4):779–87.
27. Navarro-Lopez V, Ramirez-Bosca A, Ramon-Vidal D, Ruzafa-Costas B, Genoves-Martinez S, Chenoll-Cuadros E, et al. Effect of oral administration of a mixture of probiotic strains on SCORAD index and use of topical steroids in young patients with moderate atopic dermatitis a randomized clinical trial. JAMA Dermatology. 2018;154(1):37–43.
28. Cukrowska B, Ceregra A, Maciorkowska E, Surowska B, Zegadło-Mylik MA, Konopka E, et al. The effectiveness of probiotic lactobacillus rhamnosus and lactobacillus casei strains in children with atopic dermatitis and cow’s milk protein allergy: A multicenter, randomized, double blind, placebo controlled study. Nutrients. 2021;13(4).
29. Wickens K, Black P, Stanley T V., Mitchell E, Barthow C, Fitzharris P, et al. A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clin Exp Allergy. 2012;42(7):1071–9.
30. Enomoto T, Sowa M, Nishimori K, Shimazu S, Yoshida A, Yamada K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int [Internet]. 2014;63(4):575–85. Available from: http://dx.doi.org/10.2332/allergolint.13-OA-0683
31. Marlow G, Han DY, Wickens K, Stanley T, Crane J, Mitchell EA, et al. Differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to Toll-like receptors. Pediatr Allergy Immunol. 2015;26(3):262–71.
32. Han Y, Kim B, Ban J, Lee J, Kim BJ, Choi BS, et al. A randomized trial of Lactobacillus plantarum CJLP133 for the treatment of atopic dermatitis. Pediatr Allergy Immunol. 2012;23(7):667–73.
33. RØ, Anne Dorthea Bjerkenes, Melanie Rae Simpson, Torstein Baade Rø, Ola Storrø, Roar Johnsen, Vibeke Videm TØ. Reduced Th22 cell proportion of atopic dermatitis in infants following maternal probiotic supplementation. Int J Lab Hematol. 2017;47(8):1014–21.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 WILLIAM SUCIANGTO, NADA INDIRA RAMADHANI NASRUM
This work is licensed under a Creative Commons Attribution 4.0 International License.
