EVALUASI PENGGUNAAN OSELTAMIVIR DAN AZITROMISIN PADA PASIEN COVID – 19 DI RSUD UNDATA PALU
Keywords:
Azitromisin, Covid-19, Evaluasi, OseltamiviAbstract
Wabah virus corona atau lebih dikenal dengan nama Covid–19 berdampak sampai ke Indonesia hingga
sekarang. Angka penularan virus ini terus meningkat di Indonesia dan masih tergolong tinggi sehingga kerja
sama antara pemerintah, aparat, swasta dan masyarakat terjalin dalam menanggulangi penyebaran virus
corona. Pengobatan Covid–19 diterapi dengan antivirus dan antibiotik yang menjadi salah satu fakor
penunjang keberhasilan pengobatan. Penelitian ini bertujuan untuk mengevaluasi penggunaan oseltamivir
sebagai antivirus dan azitromisin sebagai antibiotik pada terapi pasien Covid–19 ditinjau dari hasil data klinik
dan pengunaan obat di RS Undata Tahun 2020. Desain penelitian ini, yaitu kuantitatif dengan pendekatan
retrospektif, dengan populasi seluruh pasien terkonfirmasi positif covid-19 dan jumlah sampel 52 pasien yang
memenuhi kriteria inklusi yaitu pasien menerima oseltamivir dan azitromisin dan memiliki data suhu, heart
rate, respiration rate, leukosit, hasil klinik yang tertera di rekam medik. Data yang diperoleh dianalisis dengan
uji statistik Wilcoxon. Hasil penelitian menunjukkan penggunaan oseltamivir dengan persentase 11%,
sedangkan azitromisin dengan persentase 4% untuk terapi tunggal dan sebanyak 85% untuk terapi kombinasi
oseltamivir dan azitromisin. Penggunaan terapi oseltamivir dan azitromisin menunjukkan perbedaan yang
signifikan untuk suhu tubuh (p=0,002), heart rate (p=0,003) dan GCS (p=0,035), tidak ada perbedaan signifikan
untuk hasil pemeriksaan leukosit (p=0,888) dan respiration rate (p=0,333). Pemberian kombinasi oseltamivir
dan azitromisin sebagai terapi pengobatan lebih efektif dan dapat memperluas lingkup terapi dan beberapa
infeksi.
References
Anugrah, D. Arjuni, B.P. Yoyo, S. (2016) 'Rancang Bangun Pengukur Laju
Detak Jantung Berbasis Plc Mikro', Jurnal Electronics, Informatics, and Vocational Education (ELINVO), Volume 1, Nomor 3, Pendidikan Teknik
Elektro.
Arifin, Z. And Fatmawati, B.R. (2020) ‘Identifikasi Pasien Covid-19
Berdasarkan Riwayat Kontak’, 10(2), pp. 6.
Arnold, F. (2020) ‘Endemic Human Coronaviruses In Hospitalized
Adults With Community-Acquired Pneumonia: Results From The
Louisville Pneumonia Study’, Journal Of Respiratory Infections, 4(1).
doi:10.18297/Jri/Vol4/Iss1/1.
Burhan, Erlina. et al. (2020) 'Protokol Tatalaksana Covid-19 Tim
Penyusun Perhimpunana Dokter Paru Indonesia (PDPI) Perhimpunana
Dokter Spesialis Penyakit Kardiovaskular Indonesia (PERKI)
Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia (PAPDI)
Perhimpunan Dokter Anestesiologi Dan Terapi Int,Carlson, C., Kurnia, B.
And Widodo, A.D. (2018) ‘Tatalaksana Terkini
Demam Pada Anak’, Jurnal Kedokteran Meditek [Preprint].
doi:10.36452/Jkdoktmeditek.V24i67.1 684.
Donsu, Y.C. And Hasmono, D. (2020) ‘Tinjauan Azitromisin Pada
Penyakit Virus Korona 2019 (COVID-19) Review Of Azithromycin For
Coronavirus Disease 2019 (COVID- 19)’, . E, 17(2), pp. 15.
Dr. Swastika Widhiastuti, Sppddr. Swastika Widhiastuti, Sppd
(2021) ‘GERD Pada Pasien Covid-19, Efek Terapi Atau Stress?’, Primaya
Hospital, 5 August. Available At: Https://Primayahospital.Com/Covid-
/Gerd-PadaPasien-Covid-19-Efek- Terapi-Atau-Stress/(Accessed: 15
September 2021).
Gersten, T. (2020). 'Blood Differential Test', National Institutes of
Health. U.S. National Library of MedicineMedlinePlus.
https://medlineplus.gov/labtests/blood- differential/
Gersten, T. (2021) 'WBC Count', National Institutes of Health. U.S.
National Library of Medicine MedlinePlus.
Guan, W. Et Al. (2020) ‘Clinical Characteristics Of Coronavirus Disease
In China’, New England Journal Of Medicine, 382(18), pp.
–1720. doi:10.1056/Nejmoa2002032.
Hidayani, W.R. (2020) ‘Faktor Faktor Risiko Yang Berhubungan Dengan
COVID 19 : Literature Review’, pp. 15.
Hikmawati, E. And Setiyabudi, R. (2020) 'Hypertension And Diabetes
Mellitus As Covid-19 Comorbidities In Indonesia', Seminar Nasional
,Hasil Penenlitian Dan Pengabdian Pada Masyarakat V Tahun 2020
“Pengembangan Sumber Daya Menuju Masyarakat Madani Berkearifan
Lokal” LPPM – Universitas Muhammadiyah Purwokerto, ISBN: 978-
-6697-66-0 https://reference.medscape.com /drug/zithromaxzmax-
azithromycin- 342523#10 diakses pada tanggal 10 Agustus 2021.
https://reference.medscape.com /drug/tamiflu-oseltamivir-
#10 diakses pada tanggal 10 Agustus 2021.
Huang, C. et al. (2020) ‘Clinical Features Of Patients Infected With 2019
Novel Coronavirus In Wuhan, China’,The Lancet,395(10223),pp. 497–
doi:10.1016/S0140-6736(20)30183-5.
Isbaniah, Dr.F. et al. (2020) , “Pedoman Pencegahan Dan Pengendalian
Coronavirus Disease (Covid-19)’. Direktorat Jenderal Pencegahan Dan
Pengendalian Penyakit.
Ishaqui, A.A. Et al (2020). “Assessment OF Efficacy Of Oseltamivir-
Azithromycin Combination Therapy In Prevention Of Influenza-A
(H1N1)Pdm09 Infection Complications And Rapidity Of Symptoms
Relief’, Expert Review Of RespiratoryMedicine,14(5),pp.533–
doi:10.1080/17476348.2020.1730180.
Isyanto, H., Irwan, J. (2018) ' Monitoring Dua Parameter Data Medik
Pasien (Suhu Tubuh Dan Detak Jantung) Berbasis Aruino Nirkabel',
Jurusan Teknik Elektro Fakultas Teknik Universitas Muhammadiyah
Jakarta.
Kakeya, H. et al, (2014) ‘Efficacy Of Combination Therapy With
Oseltamivir Phosphate And Azithromycin For Influenza: A Multicenter,
Open-Label, Randomized Study’, Plos ONE. Edited By D.W. Cameron,
(3), pp. E91293. doi:10.1371/Journal.Pone.0091293.
Karlina Sari Sujana And Maulida, M. (2021) ‘Efektivitas N- Acetylsistein
Pada Pasien COVID-19’, 48(7), pp. 3.
Kow, C.S. And Hasan, S.S. (2020) ‘Use Of Azithromycin In COVID-19: A
Cautionary Tale’, Clinical Drug Investigation, 40(10), pp. 989–990.
doi:10.1007/S40261- 020-00961-Z.
Levani, Y., Prastya, A.D. And Mawaddatunnadila, S. (2021) ‘Coronavirus
Disease 2019 (COVID- 19): Patogenesis, Manifestasi Klinis Dan Pilihan
Terapi’, 17(1), pp. 14.
Lisni, I. et al. (2021) ' Antibiotic Profile For Covid-19 Treatment In A
Hospital In Bandung', Jurnal Ilmiah Farmako Bahari Journal Homepage:
https://journal.uniga.ac.id/index.php/JF B.
Liu, K. et al. (2020) ‘Clinical Features Of COVID-19 In Elderly Patients: A
Comparison With Young And Middle-Aged Patients’, Journal Of
Infection, 80(6), pp. E14–E18. doi:10.1016/J.Jinf.2020.03.005.
Melyana., Afrias, S. (2019) 'ImplementasiPeringatan Abnormalitas
TandaTanda Vital pada Telemedicine Workstation' p - ISSN : 2407 –
, e - ISSN : 2460 – 8416. Website :
jurnal.umj.ac.id/index.php/semnastek
Mo, P. et al. (2020) ‘Clinical Characteristics Of Refractory COVID- 19
Pneumonia In Wuhan, China’, pp. 23.
Mus, R. et al. (2021) ‘Studi Literatur: Tinjauan Pemeriksaan
Laboratorium Pada Pasien COVID- 19’, Jurnal Kesehatan Vokasional,
(4), pp 242. doi:10.22146/Jkesvo.58741.
Nining Indrawati Et al. (2021) ‘Komparasi Glasgow Coma Scale (GCS)
Dan Full Outline Of Unresponsiveness (FOUR) Untuk Menilai Mortalitas
Pada Pasien Cedera Kepala Di Area Perawatan Kritis: Literatur Review’,
Journal Of Health (Joh), 8(1), pp. 19–27. doi:10.30590/Joh.V8i1.213.
Nopitasari, B.L., et al. (2020) 'Evaluasi PenggunaanObat Antihipertensi
pada Pasien Gagal Jantung Rawat Jalan di Rumah Sakit Umum Daerah
Provinsi Nusa Tenggara Barat', Lumbung Farmasi ; Jurnal Ilmu
Kefarmasian ,Vol 1 No 2, Juli 2020 P-ISSN : 2715-5943 E-ISSN : 2715-
Paluseri, A. And Oktaviani, R. (2021) ‘Analisis Efektivitas Biaya
Penggunaan Antibiotik Levofloksasin Dan Azitromisin Pada Pasien
Penderita Corona Virus Disease-2019’, pp. 5.
Purnamasari, L. (2017) ‘Faktor Risiko, Klasifikasi, Dan Terapi Sindrom
Dispepsia’, 44(12), pp. 4.
Roeroe, P.A.L., Sedli, B.P. And Umboh, O. (2021) ‘Faktor Risiko
Terjadinya Coronavirus Disease 2019 (Covid-19) Pada Penyandang
Diabetes Melitus Tipe 2’, E-Clinic, 9(1). doi:10.35790/Ecl.V9i1.32301.
Rusdi, M.S. (2021) ‘Mini Review: Farmakologi Pada Corona Virus
Disease (Covid-19)’, 2(1), pp. 8.
Russell, C.D., Millar, J.E. And Baillie, J.K. (2020) ‘Clinical Evidence Does
Not Support Corticosteroid Treatment For 2019-Ncov Lung Injury’, The
Lancet, 395(10223), pp. 473–475.doi:10.1016/S0140 6736(20)30317-
Saminan. (2021) 'Etika Batuk Pada Masa Pandemic COVID-19', doi:
24815/Jks.V21i1.19373
Schwartz, R.A. And Suskind, R.M. (2020) ‘Azithromycin And COVID-19:
Prompt Early Use At First Signs Of This Infection In Adults And Children,
An Approach Worthy Of Consideration’, Dermatologic Therapy,33(4).
doi:10.1111/Dth.13785.
Sethi, A. And Bach, H. (2020) ‘Evaluation Of Current Therapies For
COVID-19-Treatment’, Microorganisms,8(8),pp.10
doi:10.3390/Microorganisms80810 97.
Setiadi, A.P. Et al. (2020) ‘Tata Laksana Terapi Pasien Dengan COVID-
: Sebuah Kajian Naratif’, Indonesian Journal Of Clinical Pharmacy,
(1), pp. 70. doi:10.15416/Ijcp.2020.9.1.70.
Siagian, T.H. (2020) ‘Mencari Kelompok Berisiko Tinggi Terinfeksi Virus
Corona Dengan Discourse Network Analysis’, pp. 9.
Sukmana, M. And Yuniarti, F.A. (2020) ‘The Pathogenesis Characteristics
And Symptom Of Covid-19 In The Context Of Establishing A Nursing
Diagnosis’, Jurnal Kesehatan Pasak Bumi Kalimantan, 3(1), pp. 21.
doi:10.30872/J.Kes.Pasmi.Kal.V3i1.37 48.
Sumiarty, C. And Sulistyo, F.A. (2020)
‘Hubungan Respiratory Rate (Rr) Dengan Oxygen Saturation (Spo2)
Pada Pasien Cedera Kepala’, 12, pp. 9.
Susilo, A. Et al. (2020) ‘Coronavirus Disease 2019: Tinjauan Literatur
Terkini’, Jurnal Penyakit Dalam Indonesia, 7(1), pp. 45.
doi:10.7454/Jpdi.V7i1.415.
Syamsi, N. and Andilolo, A. (2019) 'Efek Antipiretik Ekstrak Jeruk Nipis
(Fructus Citrus Aurantifolium) Pada Mencit (Mus Musculus)', Jurnal
Kesehatan Tadulako Vol. 5 No. 1, Januari 2019 : 1-63
Tantiwi, O.F. (2019) ‘Komorbiditas Gangguan Pemusatan Perhatian Dan
Hiperaktivitas Pada Anak’, Medical And Health Science Journal, 3(2)
pp.6. doi:10.33086/Mhsj.V3i2.1132.
Young, B.E. Et Al. (2020) ‘Epidemiologic Features And Clinical Course Of
Patients Infected With
Yuliana, Y. (2020) ‘Corona Virus Diseases (Covid-19): Sebuah Tinjauan
Literatur’, Wellness And Healthy Magazine, 2(1), pp. 187–192.
doi:10.30604/Well.95212020.
Zare-Zardini, H. Et al. (2020) ‘Coronavirus Disease 2019 (COVID-19) In
Children: Prevalence, Diagnosis, Clinical Symptoms, And Treatment’,
International Journal Of General Medicine, Volume 13, pp. 477–482.
doi:10.2147/IJGM.S262098
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