A Caffeic Acid Derivative Potential for Anticancer Drug: Synthesis of N-(piperidinyl)caffeamide and Its Activity against P388 Leukemia Murine Cells

Authors

Firdaus Firdaus Hasanuddin University
Nunuk Hariani Soekamto Hasanuddin University
Syadza Firdausiah Hasanuddin University
Musrifah Tahar Hasanuddin University

DOI:

https://doi.org/10.20956/ica.v13i2.10962

Keywords:

anticancer, caffeamide, caffeic acid, piperidine, P388

Abstract

Some esters and amide derivatives of p-hydroxycinnamic acid have anticancer activity. However, the amide compound is more stable to metabolic reactions compared to its ester derivative. In this research, the synthesis of a new compound, namely N-(piperidinyl)caffeamide (M5) and its anticancer activity assay, has been conducted. The compound M5 was synthesized using p-hydroxycinnamic acid and piperidine as starting materials, and the activity assay was carried out against P388 Leukemia Murine Cells by the MTT method. By these methods, the compound M5 was obtained a yellowish crystalline with a melting point of 212-214°C, and it was very active as an anticancer with an IC₅₀ value of 0.861 μg/mL. This compound was more active than the analog compounds previously synthesized.

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Published

2020-12-14

Issue

Volume 13, No 2: December 2020

Section

Articles

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