An Antioxidant and Toxicity Test as Anticancer of Jewawut Extract (Setaria italica L.) Local Varieties of West Sulawesi

Musrifah Tahar (1), Masyitha Wahid (2), Sufyan  Hakim (3)
(1) Department of Natural Sciences Education, Faculty of Teacher Training and Education, West Sulawesi University, Indonesia,
(2) Department of Biological Education, Faculty of Teacher Training and Education, West Sulawesi University, Majene, West Sulawesi, Indonesia, Indonesia,
(3) Department of Biological Education, Faculty of Teacher Training and Education, West Sulawesi University, Majene, West Sulawesi, Indonesia, Indonesia
https://doi.org/10.70561/ica.v17i2.40506

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Issue
Volume 17, No 2: December 2024
Submitted
September 28, 2024
Accepted
December 24, 2024
Published
December 30, 2024
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Abstract

Jewawut (Setaria italica L.) is a local plant that is widely found and consumed by the people of West Sulawesi. This cereal plant has various benefits, one of which is as an anticancer. So this study aims to determine the antioxidant and anticancer potential of methanol extract of Jewawut (Setaria italica L.). This research includes phytochemical test of secondary metabolites, antioxidant activity test with 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and identification of anticancer potential based on toxicity test with Brine Shrimp Lethality Test (BSLT) method. The results showed that the methanol extract of Jewawut (Setaria italica L.) contained secondary metabolite compounds including alkaloids, flavonoids, tannins, saponins, steroids and terpenoids. The extract has very weak antioxidant activity with an IC50 value of 4104.63 ppm and has potential as an anticancer with a toxicity value (LC50) of 41.65 μg/mL which means the toxicity is very strong.

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Authors

Musrifah Tahar
Department of Natural Sciences Education, Faculty of Teacher Training and Education, West Sulawesi University
musrifahtahar@unsulbar.ac.id (Primary Contact)
Masyitha Wahid
Department of Biological Education, Faculty of Teacher Training and Education, West Sulawesi University, Majene, West Sulawesi, Indonesia
Sufyan  Hakim
Department of Biological Education, Faculty of Teacher Training and Education, West Sulawesi University, Majene, West Sulawesi, Indonesia
Tahar, M., Wahid, M., & Hakim, S. (2024). An Antioxidant and Toxicity Test as Anticancer of Jewawut Extract (Setaria italica L.) Local Varieties of West Sulawesi. Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta), 17(2), 85–90. https://doi.org/10.70561/ica.v17i2.40506
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