Characterization of Compounds From Extract of Leaf Cloroform Melochia umbellata (Houtt.) Stapf var. Degrabrata K. and Test Antihiperglicemic Activities

Imran Imran (1), Nunuk Hariani Soekamto (2), Hanapi Usman (3)
(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street KM 10, Tamalanrea Makasssar, Indonesia., Indonesia,
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street KM 10, Tamalanrea Makasssar, Indonesia., Indonesia,
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street KM 10, Tamalanrea Makasssar, Indonesia., Indonesia
https://doi.org/10.20956/ica.v10i2.6650

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Issue
Volume 10, No.2: December 2017
Submitted
May 30, 2019
Accepted
May 30, 2019
Published
May 30, 2019
Keywords:
    β-sitosterol, Glucose tolerance test, chloroform extract, and Melochia umbellate
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Abstract

A research on the characterization of the chloroform extract of leaves of M. umbellata (Houtt.) stapf var. degrabrata K. and activity test as antihyperglycemic has been done. This study aimed to isolate and characterize compounds from chloroform extract and determine the optimum concentration of chloroform extract in  reducing blood glucose levels. Isolation compound from chloroform extract has been done by maceration, fractionation and purification. Based on the data of IR and NMR spectroscopic, compounds isolated from this research were β-sitosterol and fatty acid compound consisting of 25 carbon atoms. The glucose tolerance test, concentration of 6% showed a decrease in glucose levels almost equivalent with drug glibenclamide as comparator.

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Authors

Imran Imran
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street KM 10, Tamalanrea Makasssar, Indonesia.
Nunuk Hariani Soekamto
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street KM 10, Tamalanrea Makasssar, Indonesia.
noek_1512@yahoo.com (Primary Contact)
Hanapi Usman
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street KM 10, Tamalanrea Makasssar, Indonesia.
Imran, I., Hariani Soekamto, N., & Usman, H. (2019). Characterization of Compounds From Extract of Leaf Cloroform Melochia umbellata (Houtt.) Stapf var. Degrabrata K. and Test Antihiperglicemic Activities. Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta), 10(2), 1–10. https://doi.org/10.20956/ica.v10i2.6650
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