Characterization of Compounds From Extract of Leaf Cloroform Melochia umbellata (Houtt.) Stapf var. Degrabrata K. and Test Antihiperglicemic Activities
DOI:
https://doi.org/10.20956/ica.v10i2.6650Keywords:
β-sitosterol, Glucose tolerance test, chloroform extract, and Melochia umbellateAbstract
A research on the characterization of the chloroform extract of leaves of M. umbellata (Houtt.) stapf var. degrabrata K. and activity test as antihyperglycemic has been done. This study aimed to isolate and characterize compounds from chloroform extract and determine the optimum concentration of chloroform extract in reducing blood glucose levels. Isolation compound from chloroform extract has been done by maceration, fractionation and purification. Based on the data of IR and NMR spectroscopic, compounds isolated from this research were β-sitosterol and fatty acid compound consisting of 25 carbon atoms. The glucose tolerance test, concentration of 6% showed a decrease in glucose levels almost equivalent with drug glibenclamide as comparator.References
Erwin, 2010, Determination of Molecular Structure of Stem Isolates in Melochia umbellata (Houtt.) Staple var. degrabrata K. (Paliasa), unpublished dissertation, Department of Chemistry, Postgraduate Program, University of Hasanuddin, Makassar.
Heyne K., 1987, Indonesian Useful Plants, Volume III, Translation by Balit Bang Forestry, Sarana Warna Jaya Foundation, Jakarta..
Lambert, J.B., Gronert, S., Shurvell, H.F., dan Lightner, D.A., 1998, Organic Structural Spectroscopy Second Edition, Pearson, United States.
Lalo and Tayeb, 2003, Effects of Methanol Extract from Paliasa Type Kleinhovia hospita, Melochia umbellata var. degrabrata and Melochia umbellata var. Visenia of the Function of Mice Liver Induced with Carbon Tetrachloride, Pharmacy Magazine and Pharmacology, 8 (2), 25-32.
Lambert J.B., Gronert, S., Shurvell, H.F., dan Lightner, D.A., 1998, Organic Structural Spectroscopy Second Edition, Pearson, United States.
Nuvita, T., 2006, Antioxidant Activity Test of Paliasa Leaf Extract on Free Radicals Causes of Degenarative Disease, Unpublished Thesis, Makassar:Biomedical/Pharmacological Study Program of PPS UNHAS.
Purwaningsih, E., 2010, Isolation of Compounds in Chloroform Fraction of Paliasa Plant Roots (Kleinhovia hospita Linn.) And Antibacterial Activity Test of Staphylococcus aureus, Streptococcus pneumonia and Escherchia coli, unpublished Thesis, Chemistry Department of FMIPA, Hasanuddin University, Makassar.
Raflizar, Adimunca, C., and Tuminah, S., 2006, Dekali paliasa leaf (Kleinhovia hospita Linn.) As a cure for acute liver inflammation, Mirror of the World of Medicine, 50, 10-14.
Ridhay, A., 2012, Isolation, Determination of Molecular Structures, and Bioactivity Test of Secondary Metabolites from Root Wood Melochia umbellata (Houtt.) Staple var. degrabrata K., Unpublished Dissertation, Department of Chemistry, Postgraduate Program, Hasanuddin University, Makassar.
Sari, N., 2011, Isolation of Secondary Metabolites from the n-Hexane Extract Fraction of Paliasa Root Linn (Kleinhovia hospital Linn.) Which is active against Shrimp Larva Artemia salina Leach, unpublished Thesis, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar.
Soekamto, NH, Alfian, N., Iwan, D, Rudiyansyah and Merry, G., 2008, Coumarin and Steroid Compound from Stem Bark of Kleinhovia Hospita Linn, Proceedings on the International Seminar on Chemistry in The Utilization of Natural Resources, Bandung , 30-31 October.
Syahrul, E., 2010, Antihyperglycemic Effect Test of Ethanol Extract of Kaluku-kaluku Plants (Biophytum reinwardtii (Zucc.) Klotzoch) in Mice (Mus musculus), unpublished Thesis, Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar.
Downloads
Published
Issue
Section
License
This is an open access journal which means that all contents is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles in this journal without asking prior permission from the publisher or the author.
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) operates a CC BY-SA 4.0 © license for journal papers. Copyright remains with the author, but Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) is licensed to publish the paper, and the author agrees to make the article available with the CC BY-SA 4.0 license. Reproduction as another journal article in whole or in part would be plagiarism. Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) reserves all rights except those granted in this copyright notice.
