α-Glucosidase Inhibitory Activity Of Cucurbitane Derivate Isolated From Methanol Extract Of Momordica charantia L. Leaves
DOI:
https://doi.org/10.20956/ica.v12i2.8341Keywords:
Cucubitane, Momordica charantia, momordicine I, α-glucosidaseAbstract
Cucurbitane derivative has been isolated from methanol extract of the leaves of bitter melon (Momordica charantia). Purification of methanol extract using vacuum column chromatography method using n-hexane: ethyl acetate as the mobile phase was obtained a white powder isolate. This isolate was elucidated to obtain chemical structures based on spectroscopic data (FT-NMR, FT-IR, and LC-MS/MS) and resulted a cucurbitane derivate, namely momordicine I. The MeOH extract and the isolate were evaluated for α-glucosidase inhibitory effect. Both MeOH extract and momordicine I showed moderate activities with %inhibition 27.34% and 15.79 % at 100 µg/mL repectively.
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