Isolasi, Karakterisasi, dan Uji Bioaktivitas Metabolit Sekunder dari Hydroid Aglaophenia cupressina Lamoureoux Sebagai Bahan Dasar Antimikroba

Authors

  • Eva Johannes Departement of Biology, Hasanuddin University
  • Hanapi Usman Departement of Chemistry, Hasanuddin University
  • Ahyar Ahmad Departement of Chemistry, Hasanuddin University

DOI:

https://doi.org/10.20956/ica.v2i1.972

Abstract

Isolation, structure elucidation, activity test against Salmonella thypi, Staphylococcus aureus of secondary metabolite from hydroid Aglaophenia cupressina Lamoureoux, were conducted. This study was aimed to identify and isolate the compound with antibacterial properties of hydroid Aglaophenia crupessina Lamoureoux. This study used stepwise method with the following sequences: extraction, isolation, purification, structure elucidation, and bioactivity test. Study results indicated three compounds found: (1)carboxylate acid compound: hexadecanoic acid and has antibacterial properties; (2) alkaloidcompound which was considered as a new compound: aglaounhas and has antimicrobialproperties; (3) steroid compound: β-sitosterol with no antimicrobial properties.

Keywords: Isolation, characterization, secondary metabolite, Aglaophenia cupressina, Antibacterial.

References

Johnson , Karen E. Alexander Niels Lindquist and George Loo, 1999. Potent Antioxidant Actyvity of Dithiocarbamate related Compound from a Marine Hydroid. (http ://grande. Nal.usda.gov /ibids/index,php? Mode 2=detail & origin=ibidsreferences & therow=397262-diakses 5Februari 2008).

Mellisa, K. , Johnson, Karen E. Alexander Niels Lindquist and George Loo, 1999. Activity Antioksidan Potential of Hydroid. Department of Nutrition and Foodservice System. School of Human Enviromental Sciences University of North Carolina at Chapel Hill. Biochemical Pharmacology. Vol 58. 1313-1319.

Usman, H., 2006. Isolasi, Karakterisasi dan Uji Bioaktivitas Metabolit Sekunder dari Tumbuhan Cryptocarya costata. Disertasi. Jurusan Kimia Program Pascasarjana Universitas Hasanuddin. Makassar.

Wattimena, J. R., 1991. Farmakodinami dan Terapi Antibiotik. Gadjah Mada University Press, Yogyakarta.

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Published

2016-09-02

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Articles