THE EFFECT OF REALITY THERAPY ON THE SEROTONIN LEVEL AND DEPRESSION SCORE IN CERVICAL CANCER PATIENTS
DOI:
https://doi.org/10.20956/nmsj.v2i1.2253Abstract
ABSTRACT
Introduction: Cervical cancer is cancer occurring in the cervix uteri, which is mostly caused by an infection by human papillomavirus (HPV). Women diagnosed with advanced cervical cancer suffer emotional stress that can lead to depression. This condition causes decreasing quality of life, decreasing level of serotonin, and an increase in depression score. Giving reality therapy to patients is expected to have positive effects. Methods: The research was con- ducted through an experiment with pre-test and post-test design. The research samples were
15 subjects taken through consecutive sampling from the Polyclinic of Obstetrics and Gynecol- ogy of Dr. Moewardi Hospital Surakarta starting in March 2015. The analysis of serotonin level was conducted in Prodia Laboratory. The experimental data was analyzed using a t-test (α =
0.05). Results: The average level of serotonin of the research subjects after receiving reality therapy was higher (223.59 + 41.20) compared to that before the therapy (82.77 + 27.02). From the t-test analysis with p = 0.00, it was found that the average depression score after receiving reality therapy is lower (11:40 + 4.80) compared that before the therapy (17:33 +
5:52). Conclusion: There was a significant increase in the serotonin level and a significant decrease in the depression score as the effect of reality therapy given to patients with ad- vanced cervical cancer.
Keywords: Serotonin, depression score, reality therapy, advanced cervical cancer
References
Rasjidi I. Epidemilogi Kanker Serviks. In- donesian Jour nal of Cancer, 2009;3(3):103-8
Prawiroharjo S. Buku Acuan Nasional Onkologi dan Ginekologi. Jakarta: Balai Penerbit Bina Pustaka Jakarta, 2010; P:442 - 454.
Berek, Jonathan S. Psychological Is- sues, Practical Gynecologic Oncology. Philadephia: Lippincott W illiams and Wilkins, 2005;P: 836 - 880.
Li Y. Synthesis, Transport and Metabo- lism of Serotonin Formed Exogenously
Applied 5-HTP after Spinal Cord Injury in Rats. J Neurophysiol. 2014 Jan 1; 111(1): 145–163. Published online 2013 Sep 25 doi: 10.1152/jn.00508.2013
Holland JC, Alici Y. Management of dis- tress in cancer patients. J Support Oncol. 2010 Jan-Feb;8(1):4-12.
Mohammad SB. Serum Cortisol Levels in Depression Patients. Int. J. Med. Biomed. Sc. 2013;1(1):5-8
Campbell CL. Campbell LC. A System- atic Review of Cognitive Behavioral In- tervention in Advanced Cancer. Patient Educ Couns. 2012 Oct;89(1):15-24. doi: 10.1016/j.pec.2012.06.019.
Nurinasari, H.. Perbedaan Kadar Kortisol Seum Pasien Kanker Serviks Stadium Lanjut Setelah Intervensi Psikoterapi Realitas Dengan Terapi Standart. Tesis. Universitas Sebelas Maret Surakarta; 2015
Ardhianto A. Perbedaan Kadar Seroto- nin dan Skor Nyeri pada Kanker Serviks Setelah Psikoterapi Realitas. Tesis. Uni- versitas Sebelas Maret; 2015
Tama DK. Tingkat Depresi pada Pasien Kanker Serviks di RSUP H. Adam Malik Medan. Penelitian Ilmiah. Fakultas Kedokteran Universitas Sumatera Utara; 2009
Valcarolis Elizabeth, Halter. Foundation of Psychiatric Mental Health Nursing: A Clinical Approach. 6th ed. New York; 2010
Zwerenz R, Beutel ME, Imruck BH, et al. Efficacy of psychodynamic short-term psychotherapy for depressed breast cancer patients: study protocol for a ran- domized controlled trial. BMC Cancer. 2012;12:578. doi:10.1186/1471-2407- 12-578.
