Studi In Vitro dan In Silico EfektivitasEkstrak Mentimun (Cucumis sativus) dalam Menurunkan Hipertensi

Authors

DOI:

https://doi.org/10.20956/nmsj.v5i2.8181

Keywords:

Hypertension, cucumber extract, In Silico, In Vitro

Abstract

Introduction: Hypertension is one of the major causes of stroke. Stroke can be prevented by controlling hypertension. Cucumber proved to have antihypertensive effect. cucumber contains ficetin compounds that play a role in antihypertensives. This study aims to determine the effectiveness of cucumber extract to controlling hypertension. Methods: The research method used is pre-test and post-test matched control group. The 6 wistar rats were divided into 3 groups consisting of 1 treatment groups and 2 control groups. Group P1 was induced by using ketamine 0.05 ml + epinephrine 0.2 ml + 6 ml cucumber extract, group K (-) induced by ketamine 0.05 ml + epinephrine 0.2 ml without extract, and group K (+) induced by using ketamine 0.05 ml + epinephrine 0.2 ml + captopril 2.5 mg Results The results showed that epinephrine can be used as a hypertensive inducer. cucumber extract as much as 6ml can provide antihypertensive effects. In Vitro test result showed that cucumber extract can reduce blood preassure by an average decrease in blood preassure of 102 mmHg While captopril 25,5 mmHg. Conclusions: in addition to the in vitro test, the results of the in silico test showed that the cucumber extract can significantly reduce blood pressure compared to anti-hypertensive drugs (captopril). the value of fisetin in cucumber is -9.3. and captopril only -5.7.

Keywords: Hypertension, cucumber extract, In Silico, In Vitro

Author Biography

Irianto Irianto, Hasanuddin University

Departement of Physical Therapy

References

DAFTAR PUSTAKA

Ekin, S., Mestres, J., Testa, B., 2007. In

Silico Pharmacology For Drug Discovery:

Methods Fo Virtual Ligand Screening And

Profiling. British Journal of Pharmacology,

, 9-20

Lebalado, Lovindy Putri. 2015. Pengaruh

Pemberian Jus Mentimun (Cucumis

Sativus L.) Terhadap Tekanan Darah

Sistolik Dan Diastolik Pada Penderita

Hipertensi.

Li J, et all, 2012. Association of NOS3

gene polymorphism with essential

hypertension in the han populationin

southwestern china. Genetic and

molecular Researc. 2011;10(3):2202-12

Medika, M. 2011. Pengaruh Mengkudu

(Morinda citrifolia) terhadap Hipertensi

pada Kelompok Usia Lanjut. Jurnal UMY.

Vol. 11 (3): 167-174

Maheshwari,Raaz K, dkk.2014.

Invigorating Efficacy of cucumis sativas for

healt care and radiance. International

Journal Of chemistry and pharmaceutical

Science. Vol. 2(3):737-744

Winarti,C. 2005. Peluang Pengembangan

Minuman Fungsional Dari Buah

Mengkudu (Morinda Citrifolia L.). Jurnal

Litbang Pertanian,. Vol 24(4)

Syaiful,N. 2012. Efektifitas Jus Mentimun

Terhadap Penurunan Tekanan Darah

Tinggi Pada Penderita Hipertensi. Jurnal

Florence. Vol 5 (2).

Sulastri D, Liputoni. Konsumsi anti

oksidan dan ekspresi gen NOS3 alel -

T>C pada penderita hipertensi etnik

minangkabau.MBK, 2011;43(1):1-19

Syaiful,N. 2012. Efektifitas Jus Mentimun

Terhadap Penurunan Tekanan Darah

Tinggi Pada Penderita Hipertensi. Jurnal

Florence. Vol 5 (2)

Zackiyah. Dwiyanti.G, Supriyanti,

Florentina Maria Titin . 2014. Buah

mengkudu (Morinda Citrifolia L)Sebagai

Antioksidan Pada Produksi Minuman

Fungsional Yoghurt. UKSW Salatiga. Vol

Downloads

Published

2021-04-05

How to Cite

Irianto, I., Armyn, A. A. U. ., Hijriansyah, L. O. A. H. ., Hermilasari, H., & Subair, H. . (2021). Studi In Vitro dan In Silico EfektivitasEkstrak Mentimun (Cucumis sativus) dalam Menurunkan Hipertensi. Nusantara Medical Science Journal, 5(2), 61–70. https://doi.org/10.20956/nmsj.v5i2.8181