Studi In Vitro dan In Silico EfektivitasEkstrak Mentimun (Cucumis sativus) dalam Menurunkan Hipertensi
DOI:
https://doi.org/10.20956/nmsj.v5i2.8181Keywords:
Hypertension, cucumber extract, In Silico, In VitroAbstract
Introduction: Hypertension is one of the major causes of stroke. Stroke can be prevented by controlling hypertension. Cucumber proved to have antihypertensive effect. cucumber contains ficetin compounds that play a role in antihypertensives. This study aims to determine the effectiveness of cucumber extract to controlling hypertension. Methods: The research method used is pre-test and post-test matched control group. The 6 wistar rats were divided into 3 groups consisting of 1 treatment groups and 2 control groups. Group P1 was induced by using ketamine 0.05 ml + epinephrine 0.2 ml + 6 ml cucumber extract, group K (-) induced by ketamine 0.05 ml + epinephrine 0.2 ml without extract, and group K (+) induced by using ketamine 0.05 ml + epinephrine 0.2 ml + captopril 2.5 mg Results The results showed that epinephrine can be used as a hypertensive inducer. cucumber extract as much as 6ml can provide antihypertensive effects. In Vitro test result showed that cucumber extract can reduce blood preassure by an average decrease in blood preassure of 102 mmHg While captopril 25,5 mmHg. Conclusions: in addition to the in vitro test, the results of the in silico test showed that the cucumber extract can significantly reduce blood pressure compared to anti-hypertensive drugs (captopril). the value of fisetin in cucumber is -9.3. and captopril only -5.7.
Keywords: Hypertension, cucumber extract, In Silico, In Vitro
References
DAFTAR PUSTAKA
Ekin, S., Mestres, J., Testa, B., 2007. In
Silico Pharmacology For Drug Discovery:
Methods Fo Virtual Ligand Screening And
Profiling. British Journal of Pharmacology,
, 9-20
Lebalado, Lovindy Putri. 2015. Pengaruh
Pemberian Jus Mentimun (Cucumis
Sativus L.) Terhadap Tekanan Darah
Sistolik Dan Diastolik Pada Penderita
Hipertensi.
Li J, et all, 2012. Association of NOS3
gene polymorphism with essential
hypertension in the han populationin
southwestern china. Genetic and
molecular Researc. 2011;10(3):2202-12
Medika, M. 2011. Pengaruh Mengkudu
(Morinda citrifolia) terhadap Hipertensi
pada Kelompok Usia Lanjut. Jurnal UMY.
Vol. 11 (3): 167-174
Maheshwari,Raaz K, dkk.2014.
Invigorating Efficacy of cucumis sativas for
healt care and radiance. International
Journal Of chemistry and pharmaceutical
Science. Vol. 2(3):737-744
Winarti,C. 2005. Peluang Pengembangan
Minuman Fungsional Dari Buah
Mengkudu (Morinda Citrifolia L.). Jurnal
Litbang Pertanian,. Vol 24(4)
Syaiful,N. 2012. Efektifitas Jus Mentimun
Terhadap Penurunan Tekanan Darah
Tinggi Pada Penderita Hipertensi. Jurnal
Florence. Vol 5 (2).
Sulastri D, Liputoni. Konsumsi anti
oksidan dan ekspresi gen NOS3 alel -
T>C pada penderita hipertensi etnik
minangkabau.MBK, 2011;43(1):1-19
Syaiful,N. 2012. Efektifitas Jus Mentimun
Terhadap Penurunan Tekanan Darah
Tinggi Pada Penderita Hipertensi. Jurnal
Florence. Vol 5 (2)
Zackiyah. Dwiyanti.G, Supriyanti,
Florentina Maria Titin . 2014. Buah
mengkudu (Morinda Citrifolia L)Sebagai
Antioksidan Pada Produksi Minuman
Fungsional Yoghurt. UKSW Salatiga. Vol
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Nusantara Medical Science Journal
This work is licensed under a Creative Commons Attribution 4.0 International License.