PENGGUNAAN STATIN DAN ANTIPLATELET SEBAGAI PENCEGAHAN SEKUNDER KOMPLIKASI KARDIOVASKULER PADA PASIEN DIABETES MELITUS TIPE 2

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DOI:

https://doi.org/10.20956/mff.v24i2.10384

Abstract

Resistensi insulin pada pasien diabetes melitus (DM) tipe 2 dapat meningkatkan risiko terjadinya komplikasi kardiovaskuler yang selanjutnya dapat berkontribusi sebagai penyebab utama kematian. Resistensi insulin meningkatkan kerentanan pasien mengalami aterosklerosis dan menimbulkan gangguan pada fungsi platelet di pembuluh darah yang dapat berdampak pada peningkatan risiko komplikasi kardiovaskuler. Sebagai salah satu upaya untuk mencegah dan mengurangi risiko tersebut, Canadian Cardiovascular Society Guidelines tahun 2011 dan American Diabetes Association tahun 2019 merekomendasikan penggunaan golongan statin dan antiplatelet sebagai upaya pencegahan sekunder komplikasi kardiovaskuler pada pasien DM tipe 2. Penelitian ini bertujuan untuk mengetahui gambaran penggunaan statin dan antiplatelet sebagai pencegahan sekunder pada pasien DM tipe 2 dengan komplikasi kardiovaskuler. Penelitian ini bersifat observasional dengan desain cross sectional yang dilakukan pada 110 pasien di RSU Puri Raharja Denpasar Bali periode November 2019. Hasil penelitian menunjukkan bahwa dari 110 pasien yang memenuhi kriteria penggunaan statin, hanya 42 pasien (38,1%) yang menggunakan statin (simvastatin 20 mg; 95,2%). Selain itu, dari total 96 pasien yang memenuhi kriteria penggunaan antiplatelet, hanya 52 pasien (47,3%) yang menggunakan antiplatelet (aspirin 80 mg; 82,7%). Penelitian ini merefleksikan penggunaan statin yang masih rendah dalam upaya pencegahan sekunder komplikasi kardiovaskuler pada pasien DM tipe 2. Meskipun terdapat kecenderungan tingkat penggunaan antiplatelet aspirin yang lebih tinggi daripada statin dalam penelitian ini, pemberian aspirin selanjutnya masih perlu ditingkatkan lagi bersama-sama dengan peningkatan pemberian statin.

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Author Biographies

Pande Made Desy Ratnasari, Sekolah Tinggi Farmasi Mahaganesha

Program Studi Sarjana Farmasi, Kelompok Keilmuan Farmakologi dan Farmasi Klinik

Putu Dian Marani Kurnianta, Sekolah Tinggi Farmasi Mahaganesha

Program Studi Diploma Tiga Farmasi, Kelompok Keilmuan Farmakologi dan Farmasi Klinik

Anak Agung Ngurah Putra Riana Prasetya, Sekolah Tinggi Farmasi Mahaganesha

Program Studi Sarjana Farmasi, Kelompok Keilmuan Farmakologi dan Farmasi Klinik

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Published

2020-08-31

How to Cite

Ratnasari, P. M. D., Kurnianta, P. D. M., & Prasetya, A. A. N. P. R. (2020). PENGGUNAAN STATIN DAN ANTIPLATELET SEBAGAI PENCEGAHAN SEKUNDER KOMPLIKASI KARDIOVASKULER PADA PASIEN DIABETES MELITUS TIPE 2. Majalah Farmasi Dan Farmakologi, 24(2), 42-48. https://doi.org/10.20956/mff.v24i2.10384

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