HUBUNGAN ANTARA PENGGUNAAN OBAT ATORVASTATIN TERHADAP PERBAIKAN KLINIS PASIEN STROKE ISKEMIK DI RSUP DR. WAHIDIN SUDIROHUSODO
Abstract
Indonesia menduduki terbanyak di Asia yang menderita stroke. Statin dengan efek pleiotropiknya dapat menjadi neuroprotektan sehingga dapat memperbaiki kondisi klinis dan mencegah terjadinya stroke berulang, Di rumah sakit ataupun di klinik ada pasien yang mendapatkan terapi atorvastatin dan ada pula yang tidak. Penelitian ini bertujuan menganalisis efektivitas atorvastatin terhadap pasien stroke iskemik dengan menganaisis nilai kolestrol total, HDL, LDL, dan atorvastatin terhadap perbaikan klinis pasien dengan pengukuran nilai gcs dan mRS.Desain penelitian yang digunakan adalah observasional non eksperimen deskriptif-analitik. Pengambilan sampel dengan teknik non-probability sampling dengan cara purposive sampling.Jumlah sampel 30, terdiri dari kelompok atorvastatin (15 pasien) dan kelompok tanpa Atorvastatin (15 pasien). Kolestrol total, HDL, dan LDL, dan mRS diperiksa sebelum dan setelah terapi. Data kolestrol dianalisis secara deskriptif, dan nilai mRS dianalisis dengan menggunakan Uji paried t Test. Hasil penelitian menunjukkan terjadi penurunan nilai kolestrol total (25 %) dengan nilai rata-rata 194.80 dan setelah terapi 151.40, sedangkan untuk nilai HDL tidak terjadi peningkatan, sebelum terapi (31.00 setelah terapi menjadi 27.00 , dan untuk LDL tidak terjadi penurunan yang signifikan, sebelum terapi 113.80 mg/dl dan setelah terapi menjadi 93.20, sedangkan untuk perbaikan nilai mRS, memberikan hasil mRS yang meningkat secara signifikan dari kelompok atorvastatin (p=0.001) dibandingkan pasien yang tidak diterapi dengan atorvastatin (p=0.610). Dapat disimpulkan bahwa ada hubungan yang signifikan dari pemberian Atorvastatin terhadap perbaikan klinis pasien yang diukur dengan mRS (modified rankin scale)
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