ANALISIS EFEKTIVITAS DAN EFEK SAMPING PENGGUNAAN ANTIBIOTIK PADA PASIEN INFEKSI SALURAN KEMIH DI INSTALASI RAWAT INAP RSUP DR. WAHIDIN SUDIROHUSODO MAKASSAR
Abstract
Infeksi saluran kemih dapat muncul sebagai beberapa sindrom yang terkait dengan respon inflamasi terhadap invasi mikroba dan dapat berkisar dari bakteriuria asimtomatik hingga pielonefritis dengan bakteremia atau sepsis. Pilihan lini pertama terapi antibiotik pada pasien infeksi saluran kemih adalah trimethoprim–sulfamethoxazole (TMP–SMX) dan atau golongan fluoroquinolone, lini kedua golongan nitrofurantion, dan lini ketiga golongan beta-laktam. Namun pada penelitian ini, antibiotik yang paling banyak digunakan adalah antibiotik beta-laktam golongan sefalosporin generasi ketiga yaitu ceftriaxone. Penelitian ini bertujuan untuk menganalisis efektivitas penggunaan obat antibiotik,interaksi antara obat antibiotik dengan obat lain, dan efek samping yang ditimbulkan dalam pemberian antibiotik pada pasien ISK dalam mengurangi infeksi pada pasien ISKdi RSUP Dr. Wahidin Sudirohusodo Makassar. Data yang diperoleh diuji deskriptif antara penggunaan antibiotik terhadap penurunan bakteri, WBC, dan neutrofil. Penggunaan dan dosis obat antibiotik pada pasien infeksi saluran kemih di instalasi rawat inap RSUP DR. Wahidin Sudirohusodo Makassar menunjukkan hasil yang efektif dalam mengurangi dan atau menyembuhkan infeksi saluran kemih. Efek samping yang terjadi setelah pemberian antibiotik ceftriaxone yaitu mual 9%, nyeri perut 4,5%, dan pemberian antibiotik ceftazidime mengalami diare 4,5%. Interaksi yang terjadi pada pemberia antibiotik yaitu antara ceftriaxon dan furosemid, Penggunaan ceftriaxone (sefalosporin) bersamaan dengan furosemid (diuretik) dapat meningkatkan konsentrasi plasma atau menurunkan klirens dari ceftriaxon. Manajemen yang sebaiknya dilakukan adalah memonitoring fungsi ginjal
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