KAJIAN PENGGUNAAN CAPTOPRIL DAN RAMIPRIL TERHADAP PARAMETER FUNGSI GINJAL PADA PASIEN CHF
Abstract
Penelitian ini bertujuan untuk mengkaji penggunaan inhibitor ACE (Angiotensin Converting Enzyme) yaitu captopril dan ramipril pada pasien CHF berdasarkan outcome terhadap parameter fungsi ginjal di bagian PJT (Pusat Jantung Terpadu) RSUP Dr. Wahidin Sudirohusodo Makassar. Penelitian ini bertujuan untuk mengetahui efek perubahan inhibitor ACE terhadap parameter fungsi ginjal yang terjadi pada pasien CHF. Desain penelitian yang digunakan adalah penelitian observasional non eksperimen dengan rancangan deskriptif-analitik, yang mencapai jumlah 40 orang sampel. Data yang dianalisis secara deskriptif dan statistik berupa parameter fungsi ginjal. Hasil penelitian menunjukkan bahwa pasien yang menggunakan inhibitor ACE kerja singkat yaitu captopril (6,25mg/8jam) adalah 20 orang (50%) dan yang mengunakan inhibitor kerja lama yaitu ramipril (5mg/24jam) sebanyak 20 orang (50%). Data parameter fungsi ginjal dianalisis dengan menggunakan SPSS 23 melalui tes distribusi normalitas dengan menggunakan uji Normality Kolmogorov-Smirnov yang diikuti dengan uji t-tes sampel berpasangan dan uji Multivariate One Way ANOVA. Hasil menunjukkan adanya perbedaan nilai sebelum dan sesudah terapi. Kejadian peningkatan fungsi ginjal lebih besar pada data serum kreatinin p<0,05 dibandingkan pada data ureum p>0,05 pada kedua kelompok terapiReferences
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