POTENSI ANTIOKSIDAN EKSTRAK ETANOL DAUN SAMBUNG NYAWA (Gynura procumbens) TERENKAPSULASI MALTODEXTRIN DAN PENGARUHNYA TERHADAP KADAR MDA DARAH TIKUS WISTAR (Rattus novergicus) JANTAN YANG DIINDUKSI CCl4

Authors

  • Sulfiyana H. Ambo Lau Fakultas Farmasi, Universitas Hasanuddin, Makassar
  • Sartini Sartini Fakultas Farmasi, Universitas Hasanuddin, Makassar
  • Subehan Lallo Fakultas Farmasi, Universitas Hasanuddin, Makassar

Abstract

CCl4 merupakan senyawa yang dapat mengakibatkan toksisitas. Daun sambung nyawa (Gynura procumbens) merupakan salah satu tanaman yang memiliki senyawa antioksidan yang memiliki banyak berpotensi dalam bidang pengobatan. Tujuan dari penelitian ini adalah untuk mengetahui potensi antioksidan ekstrak etanol daun sambung nyawa (Gynura procumbens) yang dienkapsulasi maltodextrin terhadap kadar MDA darah tikus Wistar (Rattus novergicus) jantan yang diinduksi CCl4. Penelitian ini menggunakan 20 ekor tikus Wistar jantan yang terbagi dalam 4 kelompok yaitu kelompok 1 (kontrol sehat), kelompok 2 (CCl4), kelompok 3 (CCl4 + ekstrak 150mg/kgBB), dan kelompok 4 (CCl4 + ekstrak 300mg/kgBB). Kadar MDA diperiksa sebelum dan setelah 14 hari perlakuan. Hasil pengujian dimana ekstrak etanol daun sambung nyawa mengandung senyawa alkaloid, fenolik, flavonoid, saponin, steroid, tanin, dan terpenoid, serta kadar flavonoid total dan polifenol totalnya masing-masing yaitu 0,482% dan 2,12 %. Pengujian awal rata-rata kadar MDA tidak berbeda signifikan. Peningkatan kadar MDA yang signifikan (p<0,05) terjadi setelah perlakuan hari 14. Pemberian ekstrak dosis 150mg/kgBB dan 300mg/kgBB mencegah peningkatan kadar MDA secara signifikan, namun dosis 300mg/kgBB paling efektif menghambat peningkatan kadar MDA. Kesimpulannya bahwa ekstrak etanol daun sambung nyawa terenkapsulasi maltodextrin mampu mencegah peningkatan aktivitas peroksidasi lipid MDA paling baik pada dosis 300mg/kgBB

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Published

2019-03-18

Issue

Vol. 22 No. 3 (2018): MFF

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Articles

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