FORMULASI PATCH ANTIHIPERLIPIDEMIA DAUN SALAM (Syzygium polyanthum)
Abstract
ABSTRAK
Daun salam (Syzygium polyanthum) adalah tanaman yang telah terbukti mengurangi kadar kolesterol total dengan pengurangan kolesterol yang lebih tinggi pada kelompok dengan dosis 400 mg/kg/hari 15,4 mg / dL. Efektivitas daun salam tidak memiliki perbedaan yang signifikan dengan simvastatin dalam mengurangi kadar kolesterol. Daun salam (Syzygium polyanthum) mengandung zat aktif saponin, katekin (kelompok flavonoid), tanin, dan bahan lainnya, yaitu vitamin C, dan serat. Tujuan dari penelitian ini adalah untuk memformulasi patch stabil antihiperlipidemia dari ekstrak daun salam (Syzygium polyanthum) dengan variasi perbandingan polimer HPMC dan PVP. Evaluasi dilakukan dalam bentuk pemeriksaan organoleptik, ketebalan patch, daya serap kelembaban, susut pengering, persentase perpanjangan, keseragaman bobot, dan uji iritasi kulit. Formula yang menunjukkan hasil terbaik dari uji stabilitas fisik adalah formula dengan rasio HPMC dan PVP 1:1.
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