Malignant Melanoma of Anorectal: A Report of Two Cases

Muhammad Ihwan Kusuma | Samuel Sampetoding Bio | Ferdinandes Ferdinandes Bio | Muhammad Faruk Bio
Article History

Submited : September 5, 2021
Published : March 30, 2022

Introduction and importance:  Occurring in only 1% of cases of anorectal malignancy, malignant melanoma generally appears in the fifth and sixth decades of life, with complaints of anorectal bleeding or pain. The prognosis is generally poor. Although anorectal melanoma currently lacks a recommended treatment, surgery alone remains the primary modality treatment, the role of adjuvant therapy is generally minimal, and survival rate improves with early diagnosis. Presentation of case : Here, we report two cases of a rare malignant melanoma in the rectum treated with abdominoperineal resection and local excision.  The first case is a 60-year-old man with a history of defecating bloody stool and the appearance of a lump on the anal opening. The abdominoperineal resection was performed followed by adjuvant chemoradiotherapy.  The second case is a 51-year-old woman with a similar complaint and clinical finding with the first case. The second case was treated with a tumor excision procedure followed by adjuvant chemoradiotherapy. However, the lump was recurrence after 7 months of prior tumor excision. Discussion:    Surgical resection of anorectal melanoma is debatable. While surgical resection is still the most common treatment option, there is no agreement on whether abdominoperineal resection or local excision is the best option. Conclusions:   The abdominoperineal resection may offer a lower recurrence probability than that of tumor excision alone. However, further study is required to provide evidence-based surgical treatment


  1. Malaguarnera G, Madeddu R, Catania VE, Bertino G, Morelli L, Perrotta RE, et al. Anorectal mucosal melanoma. Oncotarget. 2018;9(9):8785–800.
  2. Cruz GMG da, Filho J de SA, Patrus G, Leite SM de O, da Silva IG, Teixeira RG, et al. Anorectal melanoma – histopathological and immunohistochemical features and treatment. J Coloproctology. 2014;34(2):95–103.
  3. Mula V, Mandal A, Britton E, Shanker VS. Direct bony invasion of malignant melanoma. Indian J Orthop. 2009 Oct;43(4):420–3.
  4. Khalid U, Saleem T, Imam AM, Khan MR. Pathogenesis, diagnosis, and management of primary melanoma of the colon. World J Surg Oncol. 2011 Dec;9(1):14.
  5. Wagner JD, Gordon MS, Chuang T-Y, Coleman JJ. Current Therapy of Cutaneous Melanoma. Plast Reconstr Surg. 2000 Apr;105(5):1774–99.
  6. Matthews NH, Li W-Q, Qureshi AA, Weinstock MA, Cho E. Epidemiology of Melanoma. In: Ward WH, Farma JM, editors. CUTANEOUS MELANOMA Etiology and Therapy. Brisbane, QLD 4122, Australia: Codon Publications; 2017. p. 3–22.
  7. Schaik P van, Ernst M, Meijer H, Bosscha K. Melanoma of the rectum: A rare entity. World J Gastroenterol. 2008;14(10):1633.
  8. Buissin D, Sterle A, Schmiegelow P, Wassenberg D, Ambe PC. Primary anorectal malignant melanoma: a rare but aggressive tumor: report of a case. World J Surg Oncol. 2015;13(1):12.
  9. Kothonidis K, Maassarani F, Couvreur Y, Vanhoute B, De Keuleneer R. Primary anorectal melanoma-a rare entity: case report. J Surg case reports. 2017 Mar;2017(3):rjx060–rjx060.
  10. Khan M, Bucher N, Elhassan A, Barbaryan A, Ali AM, Hussain N, et al. Primary anorectal melanoma. Case Rep Oncol. 2014;7(1):164–70.
  11. Van Pham B, Kang JH, Phan HH, Cho MS, Kim NK. Malignant melanoma of anorectum: Two case reports. Ann Coloproctol. 2021;37(1):65–70.
  12. Tomioka K, Ojima H, Sohda M, Tanabe A, Fukai Y, Sano A, et al. Primary Malignant Melanoma of the Rectum: Report of Two Cases. Case Rep Surg. 2012;2012:1–4.
  13. Stanojevi G, Krivokapi Z. Rare Tumors of the Colon and Rectum. In: Colorectal Cancer - Surgery, Diagnostics and Treatment. InTech; 2014.
Kusuma, M. I., Sampetoding, S., Ferdinandes, F., & Faruk, M. (2022). Malignant Melanoma of Anorectal: A Report of Two Cases. Nusantara Medical Science Journal, 7(1), 12-20.


Download data is not yet available.