Volume 6 Issue 1, January - June 2021

Introduction: The clinical usage of the ureteral stent caused several stent-related symptoms (SRSs), including lower urinary tract symptoms, pain, general health, work performance, sexual matter and additional problems. This study aims to evaluate the effectiveness between tamsulosin and solifenacin combined with tamsulosin for SRSs.
Methods: This double blind randomized controlled trial used 50 patients. Between September 2020 and February 2021, patients underwent double-J stenting after retrograde ureteroscopy were analyzed. All patients would be randomized in a 1:1 ratio in a 1:1 ratio to receive either tamsulosin 0,4 mg (Group A: 25 participants) or tamsulosin 0,4 mg & solifenacin 5 mg combination (group B: 25 participants).We used the Ureteral Symptoms Score Questionnaire (USSQ) as an outcome measure at 1^s, 2^nd, 3^rd and 4^th weeks after stent insertion. Results: Group A was found more in women, while in group B was more in men. The highest age in group A and group B was 50-60 years old (36% and 64%). The location of stenting in group A was found more in left (60%), while the group B in the right (52%). Both groups had more patients who were normal nutritional status (60%). There was an improvement in pain and work performance after treatment in both groups, meanwhile group B showed better improvement than group A at all weeks. in addition, there was an improvement in urinary symptoms and sexual matter in group B better than in group A at 2^nd to 4^th week. Furthermore, group B showed better improvement in general health and additional problem only at 4^th week. Conclusions: Combination therapy with tamsulosin and solifenacin improved USSQ score more than the monotherapy group. This implied that combination therapy is optimal for improving SRSs.

Introduction: The readmission rate due to heart failure increases every year in South Sulawesi. A Frequently used method for assessing readmission is an echocardiographic examination by measuring ejection fraction. However, recent studies show that the speckle tracking parameters are more sensitive to predict readmission of heart failure patients. In this study, we assess the role of Global Longitudinal Strain (GLS) and Global Circumferential Strain (GCS) parameters on the Echo Heart Failure Score (EHFS) as a 60-days readmission predictor in heart failure patients. Methods: We included 175 patients admitted through the inpatient installation of Integrated Heart Center Dr. Wahidin Sudirohusodo General Hospital. In addition, we reviewed up to 60 days after outpatient prospectively by collecting data through medical records. The correlation between echocardiographic parameters and readmissions was analyzed using the Spearman Rank Correlation. To determine each echocardiographic parameter's cut-off point, sensitivity, and specificity, we use Receiver Operating Characteristic (ROC) curve. Results:GLS and GCS are very sensitive and specific parameters in predicting 60-days readmission with an area under the curve (AUC) value > 0.7. This study shows that adding GLS and GCS parameters to the EHFS increases the predicted value (AUC 0.850 vs. 0.820) and sensitivity to 79%. Conclusion: GLS and GCS parameters additional on EHFS can help predict 60-days readmission of heart failure patients with sensitivity and specificity of 79% and 83%, respectively. The present study shows that with higher GLS and GCS scores on the EHFS, the risk of readmission in heart failure patients will increase.

Introduction: Brain injury is a major cause of death and disability. Computerized Tomography (CT) scanning of the brain is essential for diagnostic screening in need of neurosurgical intervention and also provide information about patient prognosis. Methods: This study is a retrospective study design to assess the comparison of the CT scan scoring system of the head with the prognostic factors of brain injury. Head CT Scans were assessed according to the following Rotterdam and Helsinki CT Scores. All patients were managed according to standard guidelines. Surgery was performed as indicated. The primary objective was mortality assessed using the Glasgow Outcome Scale (GOS) at discharge and 3 months after. Results: Altogether, 60 patients were included. The results of the ROC analysis of the two CT scoring systems, the Helsinki score provided a better sensitivity score> 80% compared to the Rotterdam score, with a positive predictive value of around 74% each for assessing the outcome (GOS) of brain injury patients Conclusions: The Helsinki score scoring system provides a better sensitivity compared to the Rotterdam score

Introduction: Open Reduction Internal Fixation (ORIF) is one of the maxillofacial bone fracture treatment procedures. Post-surgical pain is generally assessed by Numerical Rating Scale (NRS). Objective: To obtain information about pain characteristics in post-ORIF patients based on NRS. Methods: This study is an observational study with a retrospective descriptive approach. The research was conducted at Hasan Sadikin General Hospital (RSHS) Bandung in January 2018 - December 2019 based on medical record data. The data collected included age, gender, fracture area, diagnosis, duration of surgery, number of plates and screws, pre-surgical and post-surgical pain based on NRS, pain intensity measured every 8 hours postoperatively for 24 hours. Results: In this study, 65 medical records were obtained. The most frequent characteristics of the subjects were young adults aged 17-30 years (56.92%) and males (86.15%). The most frequent fracture locations were the mandible area (48.67%) and the most frequently performed surgery was at the mandibular area (60.46%). Regarding the duration of the surgery, most of the surgeries lasted for 61-120 minutes (32.30%) with the most used plates were plates (1-10 holes) and plates (11-20) holes, both having the same percentage (38.46%), and the most frequently used screw was screw (1-10) (49.23%). The most frequently used analgesics was Ketorolac (87.69%) and The NRS pain scale for ORIF was a mild type of surgery with an NRS scale of 1-3. The mean of pre-ORIF surgery patients showed a mild pain intensity with a percentage of 92.30% and postoperatively resulted in mild pain with a percentage of 95.38%. Conclusion: Characteristics of pain based on NRS in maxillofacial trauma patients treated with ORIF indicate mild pain and could be the result of the influence of analgesic drugs or subjective assessments, therefore, further research is needed to obtain a more precise assessment of the pain.

Introduction : The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global challenge since December 2019 cause by its severe symptoms and high mortality rate. Some comorbidities are associated with clinical outcomes in COVID-19 patients, one of them is cardiovascular disease, including coronary heart disease (CHD). Statins are popularly used as the lipid controller in CHD patients. Not only controlling the lipid profile, statins also can reduce the inflammation process in COVID-19 patients. This review aims to determine the activity of statins and its potential to improve the clinical manifestation of COVID-19 patients with CHD. Methods : The method used in this paper is to examine and review the literature journal that has been published last 10 years. Results : Recent studies have shown that statins capable to control the lipid, also lowering the LDL cholesterol and increasing the HDL cholesterol. And other trials have shown that statin also have ability to reduce the inflammation and inhibit further cell damage by binding mpro, a protease produced by SARS-COV2. Conclusions:  Based on those studies, we conclude that statins have the potential effect as adjuvant therapy for clinical improvement in COVID-19 patients with CHD.