PENURUNAN CD4 PADA ODHA SETELAH TERAPI ARV LEBIH DARI 39 BULAN
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Abstract
Nilai hitung CD4 telah dijadikan indikator efikasi terapi antiretroviral (ARV). Peningkatan nilai hitung CD4 diharapkan terjadi setelah terapi dilakukan, tetapi penurunan nilai hitung CD4 ditemui pada ODHA yang diterapi dalam jangka waktu lama. Anemia dianggap sebagai salah satu penyebab penurunan nilai hitung CD4. Penelitian ini bertujuan melihat hubungan terapi ARV terhadap perubahan nilai hitung CD4 sebelum dan sesudah terapi, dan hubungan anemia terhadap perubahan nilai hitung CD4. Populasi adalah ODHA yang terdaftar di RS. Mitra Masyarakat, Mimika. Sampel adalah 90 ODHA yang terdaftar di VCT RS. Mitra Masyarakat, Mimika yang sudah menerima terapi ARV lebih dari 6 bulan. Sebanyak 67 dari 90 subyek yang memiliki data CD4 sebelum dan sesudah terapi dianalisis menggunakan uji wilcoxon. Hubungan anemia dengan perubahan nilai hitung CD4 dianalisis menggunakan chi square. Mayoritas subyek penelitian adalah perempuan sebanyak 49 orang (73,1%), dengan kelompok umur 25-35 tahun yaitu 27 orang (40,3%). Sebanyak 38 orang (56,7%) diterapi ARV kurang dari 39 bulan, dan sisanya lebih dari 39 bulan. Uji statistik menunjukkan bahwa terdapat penurunan nilai hitung CD4 meskipun telah diterapi ARV, tetapi anemia bukan faktor risiko penyebab penurunan tersebut. Untuk itu, perlu dilakukan evaluasi berkesinambungan pada ODHA yang diterapi ARV.
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