EFEK PRODUK GALOHGOR TERHADAP AKTIVITAS ANTIOKSIDAN DAN PENURUNAN STRES OKSIDATIF DIABETES MELITUS TIPE 2
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Abstract
Hiperglikemi kronis pada penderita diabetes melitus tipe 2 meningkatkan terbentuknya radikal bebas yang disebabkan peningkatan peroksidasi asam lemak, yang akan mengarah pada komplikasi yang bersifat kronis. Peningkatan terbentuknya radikal bebas yang tidak diimbangi dengan peningkatan asupan antioksidan akan menimbulkan stres oksidatif. Penelitian dilakukan untuk menganalisis efek pemberian produk galohgor berupa cookies dan minuman serbuk terhadap status antioksidan dan penurunan penanda stres oksidatif pada penderita DM tipe 2. Sebanyak 18 subjek penderita DM tipe 2 dibagi menjadi 2 kelompok, yaitu kelompok intervensi (n=9) diberikan cookies dan minuman serbuk galohgor dan kelompok kontrol (n=9) diberi cookies dan minuman serbuk yang tidak mengandung galohgor selama 38 hari. Penelitian dilaksanakan di wilayah Lingkar Kampus Institut Pertanian Bogor. Aktivitas antioksidan plasma dianalisis dengan metode 2,2-diphenyl-1-pycrilhydrazyl (DPPH), sedangkan stres oksidatif dinilai dengan mengukur kadar Malondialdehyde (MDA) plasma. Data dianalisis menggunakan independent t test, paired t test dan ANCOVA. Hasil penelitian menunjukkan rata-rata selisih aktivitas antioksidan setelah dikoreksi pada kelompok intervensi dibandingkan dengan kelompok kontrol masing-masing adalah +4.07% dan +1.78% (p>0,05), sedangkan selisih MDA plasma kelompok intervensi dibandingkan dengan kelompok kontrol sebagai berikut -0,56 nmol/ml dan +7,05 nmol/ml (p<0,05). Produk galohgor berupa cookies dan minuman serbuk galohgor signifikan menurunkan stres oksidatif pada penderita DM tipe 2.
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