SUPLEMENTASI KAPSUL TEPUNG DAUN KELOR (Moringa oleifera Lam) TERHADAP SINDROM PRAMENSTRUASI PADA REMAJA
Article Sidebar
Abstract
Remaja merupakan kelompok wanita usia subur yang rentan menderita premenstrual syndrome (PMS). Daun kelor (Moringa oleifera Lam) mengandung komponen fitokimia dan bermanfaat sebagai antioksidan, antiinflamasi serta analgesik yang berpotensi menghambat prostaglandin dan aktivitas reseptor pusat nyeri. Penelitian ini bertujuan menganalisis pengaruh pemberian kapsul tepung daun kelor terhadap PMS pada remaja. Penelitian yang digunakan adalah eksperimental dengan rancangan randomized pre-post control study. Sebanyak 446 subyek remaja diskrining kemudian dipilih sampel yang memenuhi kriteria inklusi sebanyak 28 subyek yang kemudian dibagi secara random menjadi dua kelompok, yakni kelompok kontrol dan kelompok perlakuan. Analisis data dilakukan dengan menggunakan uji ANOVA dan independent t-test. Penelitian ini menunjukkan bahwa tidak terdapat perbedaan signifikan terhadap karakteristik subyek kontrol dan perlakuan sebelum diberikan intervensi kecuali pada karakteristik usia (p=0,038). Tidak terdapat perbedaan yang signifikan terhadap rerata penurunan skor PMS (p>0,05) sebelum dan setelah intervensi pada kelompok kontrol. Namun, terdapat perbedaan yang signifikan terhadap rerata skor penurunan keluhan PMS pada kelompok perlakuan (p<0,05). Hasil independent t-test menunjukkan terdapat perbedaan yang signifikan (p<0,05) terhadap rerata penurunan skor keluhan PMS antara kelompok kontrol dan kelompok perlakuan. Hasil penelitian ini menyimpulkan bahwa kapsul tepung daun kelor dapat dijadikan sebagai salah satu alternatif untuk menurunkan keluhan PMS.
References
Mahmood, A, Tanna, N. Advising on Premenstrual Syndrome. The Pharmaceutical Journal. 2013;290:442-445.
Khayat, S, Fanaei, H, Kheirkhah, M, Moghadam, ZB, Kasaeian, A, Javadimehr, M. Curcumin Attenuates Severity of Premenstrual Syndrome Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial. Complementary Therapies in Medicine. 2015;23:318324.
Surbakti F.H. Efek Minuman Fungsional Torbangun (Coleus amboinicus Lour) dan Lemon (Citrus medica var Lemon) pada Sindrom Pramenstruasi Remaja [Tesis]. Bogor: Institut Pertanian Bogor; 2015.
Taavoni, S, Barkhordari, F, Goushegir, A, Haghani, H. Effect of Royal Jelly on Premenstrual Syndrome among Iranian Medical Sciences Students: A Randomized, Triple-blind, Placebo-controlled Study. Complementary Therapies in Medicine. 2014;22:601-606.
Devi, M, Syarif, H, Damanik, R, Sulaeman, A, Setiawan, B, Dewi, R. Suplementasi Daun Torbangun untuk Menurunkan Keluhan PMS. PGM. 2010;33(2):180-194.
Khayat, S, Fanaei, H, Kheirkhah, M, Moghadam, ZB, Kasaeian, A, Javadimehr, M. Effect of Treatment with Ginger on the Severity of Premenstrual Syndrome Symptomps. ISRN Obstet Gynecol. 2014;1-5.
Halbreich, U. The Etiology, Biology, and Evolving Pathology of Premenstrual Syndromes: Clinical Procedures and Research Perspectives. Psycho neuro endocrinology. 2003; 28:55–99.
Razis, AFB, Ibrahim, MD, Kntayya, SB. Health Benefit of Moringa oleifera. Asian Pac J Cancer Prev. 2014;15(20):8571-8576.
Bhattacharya, A, Agrawal, D, Sahu, PK, Kumar, S, Mishra, SS, Patnaik, S. Analgesic Effect of Ethanolic Leaf Extract of Moringa Oleifera on Albino Mice. Indian Journal of Pain. 2014;28(2):89–94.
Adedapo, AA, Falayi, OO, Ashraf, M, Oyagbemi, AA. Evaluation of the Analgesic, Anti-inflammatory, Anti-oxidant, Phytochemical and Toxicological Properties of the Methanolic Leaf Extract of Commercially Processed Moringa oleifera in Some Laboratory Animals. J Basic Clin Physiol Pharmacol. 2015;26(5):491–499.
Vinoth, B, Manivasagaperumal, R, Balamurugan, S. Phytochemical Analysis and Antibacterial Activity of Moringa Oleifera Lam. Int J Res Biol Sci. 2012;2:98-102.
Mensah, JK, Ikhajiagbe, B, Edema, NE, Emokhor, J. Phytochemical, Nutritional and Antibacterial Properties of Dried Leaf Powder of Moringa Oleifera (lam) from Edo Central Province, Nigeria. J nat prod plant resour. 2012;2:107-12.
Muis, M, Hadju, V, Russeng, S, Naiem, MF. Effect of Moringa Leaves Extract on Occupational Stress and Nutritional Status of Pregnant Women Informal Sector Workers. Int.J.Curr. Res.Aca.Rev. 2014;2(11):86-92.
Siddharam, SM, Venketesh, GM, Thejeshwari, HL. A Study of Among Adolescent Girls in Rural Area of Hassan District, Karnataka, South India. Int J Biol Med Res. 2011;2(4):922–924.
Sianipar, O, Bunawan, CN, Almazini, P, Calista, N, Wulandari, P, Rovenska, N, Djuanda, E, Raisa, Irene, Seno, A, Suarthana, E. Prevalensi Gangguan Menstruasi dan Faktor-Faktor yang Berhubungan pada Siswi SMU di Kecamatan Pulo Gadung Jakarta Timur. Maj Kedokt Indon. 2009;7(59).
Sundari, LPR. Pemberian Kapsul Zink Per Oral Selama Empat Hari Sebelum Haid Menurunkan Kadar Prostaglandin dan Nyeri Haid Pada Penderita Nyeri Haid Primer. [Tesis]. Bali: Universitas Udayana; 2011.
Khatoon, T, Vema, KA, Kumari, R, Rupani, R, Singh, M, Rizvi, A. Age at Menarche and Affecting Bio-Social Factors Among the Girls of Lucknow, Uttar Pradesh. JIAFM. 2011; 3(33).
Canning, S, Waterman, M, Orsi, N, Ayres, J, Simpson, N, Dye, L. The Efficacy of Hypericum Perforatum (St John’s Wort) for the Treatment of Premenstrual Syndrome. CNS Drugs. 2010;24(3):207-225.
Kitamura, M, Takeda, T, Koga, S, Nagase, S, Yaegashi, N. Relationship between Premenstrual Symptomps and Dysmenorrhea in Japanese High School Students. Arch Womens Ment Health. 2012;15:131-133.
Devi, M. Suplementasi Kapsul Serbuk Daun Torbangun (Coleus amboinicus Lour) untuk Menanggulangi Keluhan Sindrom Pramenstruasi pada Remaja Putri. [Disertasi]. Bogor: Institut Pertanian Bogor; 2009.
Fozia, F, Meenu, R, Avinash, T, Abdul, AK, Shaila, F. Medicinal Properties of Moringa Oleifera: An Overview of Promising Healer. J Med Plant Res. 2012;6:4368-74.
Moyo, B, Oyedemi, S, Masika, PJ, Muchenje, V. Polypenolic Content and Antioxidant Properties of Moringa Oleifera Leaf Extracts and Enzymatic Activity of Liver from Goats Supplemented with Moringa Oleifera Leaves/Sunflower Seed Cake. Meat Sci. 2014;91(4):4417.
Bertone-Johnson, ER, Hankinson, SE, Bendich, A. Calcium and Vitamin D intake and Risk of Incident Premenstrual Syndrome. Arch Intern Med. 2005;165(11): 1246–1252.
Kulkarni, S, Dhir, A, Akula, KK. Potentials of Curcumin as an Anti-depressant. Sci World J. 2009;9:1233-41.
Lopresti, AL, Hood, SD, Drummond, PD. Multiple Anti-depressant Potential Modes of Action of Curcumin: A Review of its Anti-inflammatory, Monoaminergic, Antioxidant, Immune-modulating and Neuroprotective Effects. J Psychopharmacol. 2012;26(12):151224.
Ossewaarde, L, A van Wingen, G, Kooijman, SC, Bäckström, T, Fernández, G, Hermans, EJ. Changes in Functioning of Mesolimbic Incentive Processing Circuits During the Premenstrual Phase. SocCogn Affect Neurosci. 2011;6(5):612-20.
Kuppers, E, Ivanova, T, Karolczak, M, Beyer, C. Estrogen: A Multifunctional Messenger to Nigrostriatal Dopaminergic Neurons. J Neurocytol. 2000;29(5-6):375-85.
Rapkin, AJ dan Akopians, AL. Pathophysiology of Premenstrual Syndrome and Premenstrual Dysphoric Disorder. Menopause Int. 2012;18(2):52-9.
Anwar, F, Latif, S, Ashraf, M, Gilani, AH. Moringa Oleifera: A Food Plant with Multiple Medicinale Uses. Phytother Res. 2007;21:1725.
Hardinsyah. Meminimalkan Keluhan Menstruasi. Klinik Konsultasi Gizi dan Klub Diet GMSK. Bogor: Insttitut Pertanian Bogor; 2004.
Rosenfeld, R, Livne, D, Nevo, O, Dayan, L, Milloul, V, Lavi, S, Jacob, G. Hormonal and Volume Dysregulation in Women with Premenstrual Syndrome. Hypertension. 2008;51:1225-1230.
Khabibah, N. Uji Efek Diuretik Ekstrak Buncis (Phaseolus Vulgaris L) pada Tikus Putih Jantan Galur Wistar [Skrispi]. Ungaran: STIKES Ngudi Waluyo; 2011.
Linder, M. Biokimia Nutrisi dan Metabolisme. Jakarta: Penerbit Universitas Indonesia; 1992.
Marcu, M. Miracle Tree. Amerika: Soundconcepts; 2015.
Facchinetti, F, Borella, P, Sances, G, Fioroni, L, Nappi, R, Genazzani, A. Oral Magnesium Successfully Relieves Premenstrual Mood Changes. Obstetrics and Gynecology. 1991;78(2):177-81.
Pérez-López, FR, Chedraui, P, Pérez-Roncero, G, López-Baena, MT, Cuadros-López, JL. Pramenstrual Syndrome and Pramenstrual Dysphoric Disorder: Symptoms and Cluster Influences. The Open Psychiatry Journal. 2009;(3):39-49.
Goyal, BR, Agrawal, BB, Goyal, RK, Mehta, AA. Phytopharmacology of Moringa Oleifera Lam: An Overview. Nat Prod Rad. 2007;6:347-53.
Bakre, AG, Aderibigbe, AO, Ademowo, OG. Studies on Neuropharmacological Profile of Ethanolic Extract of Moringa Oleifera Leaves in Mice. Journal of Ethnopharmacology. 2013;149(3):783-789. Abstract.
Authors
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Atribusi-NonKomersial-BerbagiSerupa 4.0 Internasional License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Copyright encompasses rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations. The reproduction of any part of this journal, its storage in databases and its transmission by any form or media, such as electronic, electrostatic and mechanical copies, photocopies, recordings, magnetic media, etc.
All articles published Open Access are free for everyone to read and download. Under the CC-BY-NC-SA license, authors retain ownership of the copyright for their article, but authors grant others permission to use the content of publications in Media Kesehatan Masyarakat Indonesia Universitas Hasanuddin in whole or in part provided that the original work is properly cited. Users (redistributors) of Media Kesehatan Masyarakat Indonesia Universitas Hasanuddin are required to cite the original source, including the author's names, Media Kesehatan Masyarakat Indonesia Universitas Hasanuddin as the initial source of publication, year of publication, and volume number.
Media Kesehatan Masyarakat Indonesia Universitas Hasanuddin is licensed under Creative Commons Atribusi-NonKomersial-BerbagiSerupa 4.0 Internasional.
