KADAR ENZIM KOLINESTERASE TIKUS WISTAR (Rattus norvegicus) YANG TERPAPAR SIPERMETRIN
Abstract
Sipermetrin bersifat neurotoksin dan dapat mempengaruhi kadar enzim kolinesterase. Sipermetrin ditemukan terdapat pada produk Jambal Roti dengan kadar yang melebihi batas maksimum residu yang diperkenankan SNI dan CAC. Penelitian ini bertujuan untuk mengetahui pengaruh sipermetrin terhadap kadar enzim kolinesterase Tikus Wistar (Rattus norvegicus). Tikus diberi perlakuan paparan sipermetrin dengan dosis 0,00 mg/kg (K-), 0,05 mg/kg, 0,60 mg/kg, 1,10 mg/kg, 1,60 mg/kg, 2,15 mg/kg dan daging ikan yangmengandung sipermetrin 1,73 mg/kg (kontrol positif : K+). Kadar enzim kolinesterase darah tikus ditetapkan berdasarkan metode Enzymatic Photometric. Hasil menunjukkan bahwa sipermetrin berpengaruh terhadap penurunan kadar enzim kolinesterase Tikus Wistar. Kadar enzim kolinesterase terendah pada perlakuan paparan sipermetrin dosis 2,15 mg/kg yaitu 4059.9 U/L.
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