Risk Factors of Chronic Kidney Disease in Indonesian Patients with Diabetes Mellitus

Asy Syifa Anwari Zahra (1), Chandrayani Simanjorang (2)
(1) Department of Public Health, Faculty of Health Sciences, University of Pembangunan Nasional “Veteran” Jakarta, Indonesia, Indonesia,
(2) Department of Public Health, Faculty of Health Sciences, University of Pembangunan Nasional “Veteran” Jakarta, Indonesia, Indonesia

Abstract

Chronic Kidney Disease (CKD) is a public health problem with increasing prevalence and incidence. About 1 in 3 adults with Diabetes Mellitus (DM) has CKD. This study aims to determine the risk factors for Chronic Kidney Disease in Diabetes Mellitus (CKD-DM) patients in Indonesia. A cross-sectional study was conducted with secondary data, Indonesia Basic Health Research 2018. Data analysis was carried out univariate, bivariate, and multivariate. Also, spatial analysis was carried out to map the prevalence of cases. Among 14.932 samples, the prevalence of CKD-DM in Indonesia was 1.8%. Multivariate analysis results found that gender (aPR=3.24; 95%CI 3.182-3.306), every day smoker (aPR: 2.47; 95%CI 2.415 – 2.535), someday smoker (aPR=1.93; 95%CI 1.875 – 1.987), hypertension (aPR=1.56; 95%CI 1.540 – 1.591), pre elderly (aPR=1.13 95%CI 1.098 – 1.158), elderly (aPR=0.81; 95%CI 0.790 – 0.834), exercise (aPR =1.07; 95%CI 1.055 – 1.090), and obesity (aPR=0.90; 95%CI 0.891 – 0.924) have a significant relationship with the incidence of CKD-DM in Indonesia. This study found that gender is the dominant variable in the incidence of CKD-DM in Indonesia. It is desired that healthcare providers and program makers should recognize gender differences in the progression of CKD and conduct screening program for risk factors of CKD-DM.

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References

1. Maghfiroh AA, Simanjorang C, Simawang AP, Pramesti LT, Wasir R. Faktor-Faktor Yang Berhubungan Dengan Kejadian Gagal Ginjal Akut Pada Anak: a Literature Review. Prepotif Jurnal Kesehatan Masyarakat. 2023;7(1):41–51. https://journal.universitaspahlawan.ac.id/index.php/prepotif/article/view/10527

2. CDC. Chronic Kidney Disease Basics. cdc.gov; 2022.

3. CDC. Diabetes and Chronic Kidney Disease. cdc.gov; 2022.

4. Harjutsalo V, Groop PH. Epidemiology and Risk Factors for Diabetic Kidney Disease. Advances in Chronic Kidney Disease. 2014;21(3):260–266. http://dx.doi.org/10.1053/j.ackd.2014.03.009

5. Yu MK, Lyles CR, Bent-Shaw LA, Young BA. Risk Factor, Age and Sex Differences in Chronic Kidney Disease Prevalence in a Diabetic Cohort: The Pathways Study. American Journal of Nephrology. 2012;36(3):245–251. http://dx.doi.org/10.1159/000342210

6. Afkarian M. Diabetic Kidney Disease in Children and Adolescents. Pediatric Nephrology. 2015;30:65–74. http://dx.doi.org/10.1007/s00467-014-2796-5

7. Hussain S, Chand Jamali M, Habib A, Hussain MS, Akhtar M, Najmi AK. Diabetic Kidney Disease: An Overview of Prevalence, Risk Factors, and Biomarkers. Clinical Epidemiology and Global Health. 2021;9(1):2–6. https://doi.org/10.1016/j.cegh.2020.05.016

8. Deng Y, Li N, Wu Y, Wang M, Yang S, Zheng Y, et al. Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019. Front Endocrinol (Lausanne). 2021;12(1)1-15. https://doi.org/10.3389/fendo.2021.672350

9. Liyanage T, Toyama T, Hockham C, Ninomiya T, Perkovic V, Woodward M, et al. Prevalence of Chronic Kidney Disease in Asia: A Systematic Review and Analysis. BMJ Glob Heal. 2022;7(1):1–9. https://doi.org/10.1136/bmjgh-2021-007525

10. Kemenkes RI. Laporan Nasional RKD 2018. Jakarta: Kementerian Kesehatan RI; 2018.

11. PERNEFRI. 9th Report of Indonesian Renal Registry 2016. Jakarta: Perhimpunan Nefrologi Indonesia; 2017.

12. BPJS. Program SCF Bantu Jaga Likuiditas Rumah Sakit. Jakara: Badan Penyelenggara Jaminan Sosial Kesehatan; 2020.

13. Liu P, Sawhney S, Heide-Jørgensen U, Quinn RR, Jensen SK, McLean A, et al. Predicting the Risks of Kidney Failure and Death in Adults with Moderate to Severe Chronic Kidney Disease: Multinational, Longitudinal, Population Based, Cohort Study. BMJ. 2024; 15(1):1-12. https://doi.org/10.1136/bmj-2023-078063

14. Tim Riskesdas. Laporan Provinsi Maluku Utara Riskesdas 2018. Maluku Utara; Dinas Kesehatan Maluku Utara: 2018.

15. Tim Riskesdas. Laporan Riset Kesehatan Dasar 2018 Provinsi Sulawesi Tenggara. Sulawesi Tenggara; Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan (LPB): 2018.

16. Oshima M, Iwata Y, Toyama T, Kitajima S, Hara A, Sakai N, et al. Sex Differences in Risk Factors for End-Stage Kidney Disease and Death in Type 2 Diabetes: A Retrospective Cohort Study. Journal of Diabetes. 2023. 15(3):246–254. https://doi.org/10.1111/1753-0407.13367

17. Harris RC, Zhang MZ. The Role of Gender Disparities in Kidney Injury. Annals of Translational Medicine. 2020;8(7):1–3. https://doi.org/10.21037/atm.2020.01.23

18. Nazzal Z, Hamdan Z, Masri D, Abu-Kaf O, Hamad M. Prevalence and Risk Factors of Chronic Kidney Disease in Palestinian Patients with Diabetes: a Cross-Sectional Study. The Lancet. 2022;399(Supplement 1):S8. http://dx.doi.org/10.1016/S0140-6736(22)01143-6

19. Gündoğdu Y, Anaforoğlu İ. Effects of Smoking on Diabetic Nephropathy. Front Clin Diabetes Healthc. 2022;3(1):1–7. https://doi.org/10.3389/fcdhc.2022.826383

20. Sutadji JT, Pranoto A, Prasetyo RV. Risk Factors of Chronic Kidney Disease (CKD) in Type 2 Diabetes Mellitus (DM) Patients at Dr. Soetomo General Academic Hospital, Surabaya. JUXTA Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga. 2023;14(1):12–16. https://doi.org/10.20473/juxta.V14I12023.12-16

21. Van Buren PN, Toto R. Hypertension in Diabetic Nephropathy: Epidemiology, Mechanisms, and Management. Advances in Chronic Kidney Disease. 2011;18(1):28–41. https://doi.org/10.1053/j.ackd.2010.10.003

22. Xie D, Ma T, Cui H, Li J, Zhang A, Sheng Z, et al. Global Burden and Influencing Factors of Chronic Kidney Disease Due to Type 2 Diabetes in Adults Aged 20–59 Years, 1990–2019. Scientific Reports. 2023;13(1):1–11. https://doi.org/10.1038/s41598-023-47091-y

23. Yang Y, Wang N, Jiang Y, Zhao Q, Chen Y, Ying X, et al. The Prevalence of Diabetes Mellitus with Chronic Kidney Disease in Adults and Associated Factors in Songjiang District, Shanghai. Annals of Palliative Medicine. 2021;10(1):7214-7224. https://doi.org/10.21037/apm-21-803

24. Wang X, Yan N, Pan R, Dang Y, Wang L. Examining the Links Between Physical Activity, Sitting Time, and Renal Function in T2DM Patients. Diabetes, Metabolic Syndrome and Obesity. 2023;16(1):2469–2476. https://doi.org/10.2147/DMSO.S408677

25. Xia Y, Jiang C, Lu J, Liu J, Gu T, Bi Y. Associations Between Obesity and Kidney Disease in Chinese Men and Women With Type 2 Diabetes: A Retrospective Cohort Study. Canadian Journal of Diabetes. 2022;46(1):47-52. https://doi.org/10.1016/j.jcjd.2021.05.005

26. Zhang Y, Guo Y, Shen X, Zhao F, Yan S. Lower Body Mass Index is Not of More Benefit for Diabetic Complications. Journal of Diabetes Investigation. 2019;10(5):1307–1317. https://doi.org/10.1111/jdi.13003

Authors

Asy Syifa Anwari Zahra
Chandrayani Simanjorang
chandrayanis@upnvj.ac.id (Primary Contact)
Zahra, A. S. A., & Simanjorang, C. (2024). Risk Factors of Chronic Kidney Disease in Indonesian Patients with Diabetes Mellitus. Media Kesehatan Masyarakat Indonesia, 20(3), 102–111. https://doi.org/10.30597/mkmi.v20i3.33053

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