Adaptation of Moringa Leaf Extract on Hemoglobin and Arm Circumference in Adolescent Girls Semarang
Abstract
Adolescent malnutrition, particularly anemia, remains a major public health challenge in developing countries, including Indonesia, as it increases the risk of growth retardation, developmental disorders, poor pregnancy outcomes, and infectious diseases. Nutritional interventions during adolescence are crutial for improving health and breaking the intergenerational cycle of malnutrition. This study aimed to analyze the effect of Moringa oleifera capsules on hemoglobin (Hb) levels and Mid-Upper Arm Circumference (MUAC) among adolescent girls in Semarang. A quasi-experimental study with a pretest–posttest control group design was conducted in two junior high schools in Semarang (SMPN 39 and SMPN 8), involving 102 female students aged 13–15 years, who were selected using purposive sampling. Participants were assigned to an intervention group (n = 51) receiving 300 mg of Moringa oleifera capsules twice weekly for 6 months under teacher supervision, and a control group (n = 51) receiving no supplementation. Data were collected at baseline and after the intervention, including Hb measurement (Hemocue analyzer) and MUAC. Data were analyzed using paired t-tests and independent t-tests. Results showed a significant improvement in Hb levels in the intervention group (mean pretest 11.58±0.87 g/dL; posttest 13.65±0.89 g/dL; p<0.001), whereas no significant change was found in the control group (p = 0.132). MUAC also increased significantly in the intervention group (pretest 25.50±4.06 cm; posttest 26.21±4.94 cm; p = 0.002), with a greater improvement compared to the control group (p = 0.002). In conclusion, supplementation with Moringa oleifera effectively improved Hb levels and MUAC among adolescent girls. This intervention has potential as a practical and affordable strategy for preventing anemia and improving nutritional status in adolescents.
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References
1. Paul D, Chakraborti C, Mishra P. Factors Affecting Malnutrition of Rural Adolescent Girls: Evidences from Selected Districts of West Bengal. Children and Youth Service Review. 2023;152:1-14. https://doi.org/10.1016/j.childyouth.2023.107065
2. WHO. Nutritional Anaemias: Tools for Effective Prevention and Control. World Health Organization; 2017:1–83. https://www.who.int/publications/i/item/9789241513067
3. Madjdian DS, Talsma EF, Vaandrager L, Gupta A Sen, van de Geest JMJ, Koelen M, et al. Nourishing Hope? Changes in Malnutrition and Changes in Girls’ Aspirations - Evidence from the Suaahara II Adolescent Girls Panel in Nepal. Journal of Adolescent Health. 2022;70(4):617–624. https://doi.org/10.1016/j.jadohealth.2021.10.029
4. Anisa Y, Siti A, Sri H. Faktor-Faktor yang Berhubungan dengan Anemia pada Remaja Putri. Lentera Perawat. 2024;5(1):10–17. https://doi.org/10.52235/lp.v5i1.276
5. Yuan M, Tang T, Li Y, Wang X, Wang C, Zhang X, et al. Associations of Metals with Hemoglobin and Anemia in a Chinese Early Adolescent Cohort. Ecotoxicology and Environmental Safety. 2025;295:1-12. https://doi.org/10.1016/j.ecoenv.2025.118122
6. Suprapti E, Hadju V, Ibrahim E, Indriasari R, Erika KA, Balqis B. Anemia: Etiology, Pathophysiology, Impact, and Prevention: A Review. Iranian Journal of Public Health. 2025;54(3):509-520. https://doi.org/10.18502/ijph.v54i3.18244
7. Mulyana DW, Zain IM. Pengaruh Tingkat Pengetahuan, Pendidikan, Pendapatan, dan Perilaku terhadap Status Balita Gizi Buruk di Kecamatan Tegalsari dan di Kecamatan Tandes Kota Surabaya. Jurnal Online UNESA. 152-162. https://share.google/Z8YHZSoM2DNlax0Sn
8. Darling AM, Fawzi WW, Barik A, Chowdhury A, Rai RK. Double Burden of Malnutrition Among Adolescents in Rural West Bengal, India. Nutrition. 2020;79–80:110809. https://doi.org/10.1016/j.nut.2020.110809
9. Indriyani S, Kusharisupeni K, Adawiyah AR. Determinan Anemia pada Remaja Putri. Jurnal Ilmu Kesehatan Masyarakat. 2024;13 (2):149–157. https://doi.org/10.33221/jikm.v13i02.2709
10. Suciyanti D, Kolopaking R, Mustafa A, Iwan S, Witjaksono F, Fahmida U. Effect of Optimized Food-Based Recommendations on Nutrient Intakes, Hemoglobin Levels, and Memory Performance of Adolescent Girls in East Java, Indonesia. Nutrition Journal. 2025 24;24(1):1-10. https://doi.org/10.1186/s12937-024-01061-w
11. Nurhasanah I. Penyuluhan Sebagai Upaya Peningkatan Pengetahuan Tentang Anemia pada Remaja Putri Pondok Pesantren Slafiyah Syafi’iyah Sukorejo Situbondo. Pengabdian Masyarakat Cendekia (PMC). 2023. 27;2(1):23–25. https://doi.org/10.55426/pmc.v1i2.233
12. Rahman RA, Fajar NA. Analisis Faktor Risiko Kejadian Anemia pada Remaja Putri: Literatur Review. Jurnal kesehatan Komunitas (Journal of Community Health). 2024.10(1):133–140. https://doi.org/10.25311/keskom.Vol10.Iss1.1403
13. Kasim F, Sirajuddin S, Amiruddin R. The Effect of Moringa Oleifera Leaf Biscuit on the Increase of Body Weight and Upper Arm Circumference for Chronic Energy Deficiency among Pregnant Women in Bontoramba District Jeneponto Regency. Indian Journal of Public Health Research and Development. 2019;10(4):1018. https://doi.org/10.5958/0976-5506.2019.00842.8
14. Semarang City Health Office. Anemia. 2022.
15. Gopalakrishnan L, Doriya K, Kumar DS. Moringa Oleifera: A Review on Nutritive Importance and Its Medicinal Application. Food Science and Human Wellness. 2016;5(2):49–56. https://doi.org/10.1016/j.fshw.2016.04.001
16. Setyaningrum, Ira Y, Wulandari I, SWP. Literature Review Penyebab dan Upaya Pecegahan Anemia pada Remaja Putri. Journal of Noncommunicable Diseases. 2023;3 (2):84–100. http://dx.doi.org/10.52365/jond.v3i2.858
17. Fahey J.W. Moringaoleifera: A Review of The Medical Evidence for Its Nutritional, Therapeutic, and Prophylactic Properties. Trees Life Journal. 2005;1(5):1-25. http://www.tfljournal.org/article.php/20051201124931586
18. Alwi J, Dahlia B, Ibrahim MS, Fandir A, Anwar R, Hurfiati. Comparative of Moringa (Moringa oleifera) Cookies and Capsules on Hemoglobin Levels in Adolescent Girls with Iron Deficiency Anemia. Media Gizi Kesmas. 2025;14(1):87–93. https://doi.org/10.20473/mgk.v14i1.2025.87-93
19. Khanam M, Sanin KI, Ara G, Sultana RR, Boitchi AB, Farzana FD, et al. Effects of Moringa Oleifera Leaves on Hemoglobin and Serum Retinol Levels and Underweight Status Among Adolescent Girls in Rural Bangladesh. Frontiers Nutrition. 2022; 9:959890. https://doi.org/10.3389/fnut.2022.959890
20. Khofifah N, Mardiana. The Moringa Leaf (Moringa Oleifera) Biscuits Have an Effect on Hemoglobin Levels in Anemic Adolscent Girls. AcTion: Aceh Nutrition Journal. 2023;8(1):43–50. http://dx.doi.org/10.30867/action.v8i1.614
21. Sholicha CA, Muniroh L. Hubungan Asupan Zat Besi, Protein, Vitamin C dan Pola Menstruasi Dengan Kadar Hemoglobin Pada Remaja Putri Di SMAN 1 Manyar Gresik. Media Gizi Indonesia. 20191;14(2):147-153. https://doi.org/10.204736/mgi.v14i2.147–153
22. Astuti AB, Mulyanti S, Diyono. The Effectiveness of the Interprofessional Collaboration (IPC) Program on The Attitude of Mothers and Health Cadres on Stunting at Puskesmas Karanganom Klaten Central Java Republic of Indonesia. Electronic Journal of General Medicine. 2021;18(6):1-5. https://doi.org/10.29333/ejgm/11315
23. Koul B, Chase N. Moringa Oleifera Lam.: Panacea to Several Maladies. Journal of Chemical and Pharmaceutical Research. 2015;7(6):687–707.
24. Sokhela H, Govender L, Siwela M. Complementary Feeding Practices and Childhood Malnutrition in South Africa: The Potential of Moringa Oleifera Leaf Powder as a Fortificant: A Narrative Review. Nutrients. 2023;15(8):1-17. https://doi.org/10.3390/nu15082011
25. Mauliku N, Darmawan FH, Yuliana H, Murtiani F, Norma N. The Effect of Moringa (Moringa Oleifera L.) Leaf Extract Capsules in Increasing Hemoglobin Levels in Adolescent Girls. Indonesian Journal of Global Health Research. 2024;7(1):303–310. https://doi.org/10.37287/ijghr.v7i1.4293
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